AI Article Synopsis
- The study investigates the impact of existing interferon γ (IFN-γ) responses on tuberculosis severity in HIV-infected individuals who have received BCG vaccination.* -
- Results show that higher baseline IFN-γ responses to specific mycobacterial antigens correlate with lower levels of tuberculosis bacteria in sputum samples and quicker culture positivity.* -
- This relationship is particularly pronounced in participants who received an investigational tuberculosis vaccine, suggesting a potential protective role of preexisting IFN-γ responses in HIV-associated tuberculosis.*
Article Abstract
The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCG-immunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805244 | PMC |
| http://dx.doi.org/10.1093/infdis/jit396 | DOI Listing |
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