Intracranial fungal infections are unusual and typically described in immunocompromised hosts. The authors describe a rare case of an immunocompetent white man presenting with blindness after Aspergillus fumigatus infection of the ethmoidal air sinus with spread to the orbital apex and the frontal lobe. This was successfully treated by surgical drainage via a frontal craniotomy and long-term antifungal therapy with voriconazole.
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http://dx.doi.org/10.1055/s-0033-1345092 | DOI Listing |
World J Radiol
December 2024
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India.
Background: Invasive fungal sinusitis (IFS) can present as a mild disease to life-threatening infection. A recent surge in cases was seen due to the coronavirus disease 2019 (COVID-19) pandemic. Many patients require surgical debridement and hence imaging [contrast-enhanced computed tomography (CECT) of the paranasal sinuses (PNS)] to document the extent of the disease.
View Article and Find Full Text PDFAm J Trop Med Hyg
December 2024
Department of Dermatology, The Second Hospital of Jilin University, Changchun, People's Republic of China.
Mycetoma is a granulomatous disease of subcutaneous tissue that is caused by different species of aerobic filamentous bacteria (actinomycetoma) or fungi (eumycetoma). Mycetoma treatment depends on the causative pathogen, and it mainly consists of antimicrobial interventions or surgery. Aspergillus terreus is an etiologic agent of invasive aspergillosis and a rare cause of eumycetoma that is common in central and southern China.
View Article and Find Full Text PDFJ Fungi (Basel)
November 2024
Faculty of Medicine, Pathology Department, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey.
Invasive aspergillosis is a rare but severe fungal infection primarily affecting immunocompromised individuals. The Disease-2019 (COVID-19) pandemic has introduced new complexities in managing aspergillosis due to the widespread use of corticosteroids for treating COVID-19-related respiratory distress, which can increase susceptibility to fungal infections. Here, we present a challenging case of progressive cerebral aspergillosis complicated by cavernous sinus thrombosis (CST) in a 67-year-old male with a history of COVID-19.
View Article and Find Full Text PDFMed Mycol
November 2024
Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.
Owing to their inherent resistance to different classes of antifungals, early identification of Fusarium spp. is crucial. In this study, 10 clinical isolates were included from patients with invasive fusariosis involving lungs, sinuses, or both.
View Article and Find Full Text PDFHead Neck Pathol
October 2024
Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh City, 700000, Vietnam.
Background: Invasive fungal rhinosinusitis (IRFS) is a rare but highly fatal disease. The two primary groups of pathogens, Mucorales and Aspergillus, require different treatments and have distinct prognoses.
Purpose: This study aimed to analyze the histopathological features of IFRS.
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