[Light-chain escape from plateau phase].

Ann Biol Clin (Paris)

Service d'hématologie clinique, Hôpital militaire d'instruction Mohammed V, Rabat, Maroc.

Published: November 2013

We report the first case of light-chain escape from plateau phase occurring after 7 years of evolution of multiple myeloma in a patient who had never received new molecules. A very good partial response was obtained.

Download full-text PDF

Source
http://dx.doi.org/10.1684/abc.2013.0864DOI Listing

Publication Analysis

Top Keywords

escape plateau
8
[light-chain escape
4
plateau phase]
4
phase] report
4
report case
4
case light-chain
4
light-chain escape
4
plateau phase
4
phase occurring
4
occurring years
4

Similar Publications

Biomass holds significant potential for large-scale synthesis of hard carbon (HC), and HC is seen as the most promising anode material for sodium-ion batteries (SIBs). However, designing a HC anode with a rich pore structure, moderate graphitization and synthesis through a simple process using a cost-effective precursor to advance SIBs has long been a formidable challenge. This is primarily because high temperatures necessary for pore regulation invariably lead to excessive graphitization.

View Article and Find Full Text PDF
Article Synopsis
  • Alzheimer's Disease (AD) is the most common form of dementia, and despite advances in research, effective clinical treatments are still lacking. Apigenin, a natural flavonoid found in foods and herbs, is being studied for its potential therapeutic effects on AD.
  • A thorough search of medical databases identified 13 studies involving 736 animals, which revealed that apigenin treatment positively influenced AD symptoms, such as decreasing escape latency and increasing time spent in target areas, while also reducing certain inflammatory and apoptotic markers in the brain.
  • Although the findings suggest that apigenin shows promise in treating AD in animal models, more clinical research is needed to determine its effectiveness in humans.
View Article and Find Full Text PDF
Article Synopsis
  • A study conducted in France during the 2023-24 RSV season analyzed the effectiveness of nirsevimab, a monoclonal antibody, in preventing RSV infections in infants, focusing on breakthrough cases.
  • Out of 695 RSV-infected infants, researchers sequenced the full-length RSV genome of 545 infants, identifying that 48% had breakthrough infections despite receiving nirsevimab.
  • While no resistance was found in RSV-A infections from nirsevimab-treated infants, two cases of RSV-B showed substitutions linked to resistance, indicating a potential concern for the antibody's effectiveness against this variant.
View Article and Find Full Text PDF

Innovation in viruses: fitness valley crossing, neutral landscapes, or just duplications?

Virus Evol

September 2024

INSA Lyon, INRIA, CNRS, Universite Claude Bernard Lyon 1, Ecole Centrale de Lyon, Université Lumière Lyon 2, LIRIS, UMR5205, Villeurbanne 69621, France.

Viruses evolve by periods of relative stasis interleaved with sudden, rapid series of mutation fixations, known as evolutionary bursts. These bursts can be triggered by external factors, such as environmental changes, antiviral therapies, or spill-overs from reservoirs into novel host species. However, it has also been suggested that bursts may result from the intrinsic evolutionary dynamics of viruses.

View Article and Find Full Text PDF

What can we learn from the experiment of electrostatic conveyor belt for excitons?

J Phys Condens Matter

October 2024

Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, People's Republic of China.

Article Synopsis
  • Scientists studied excitons, which are special particles made of an electron and a hole, to understand how they move and create patterns in experiments.
  • They found that patterns close to the light source came from "hot" excitons acting like regular particles, while patterns farther away came from "cooled" excitons that behave differently.
  • By using a complex equation, they modeled how these excitons move over time and found results that matched experiments, showing that how quickly excitons cool down is key to their movement.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!