AI Article Synopsis
- The study tests if urine N-acetyl-beta-D-glucosaminidase (NAG) can serve as a biomarker for acute kidney injury in patients who have ingested paraquat poison.
- The research involved 44 paraquat-intoxicated patients and 40 healthy controls, measuring urine NAG levels using spectrophotometry.
- Results showed higher NAG levels in paraquat patients compared to controls, and those with higher NAG levels had a significantly greater mortality rate, indicating NAG's potential as an early indicator of kidney injury and a predictor of death in such cases.
Article Abstract
Objectives: To test the hypothesis that urine N-acetyl-beta-D-glucosaminidase (NAG) is a nearly biomarker for acute kidney injury in patients with acute paraquat poisoning.
Methods: Forty-four patients with paraquat intoxication and 40 age and gender-matched healthy control participants were recruited. The urine N-acetyl-beta-D-glucosaminidase was determined by spectrophotometric methods.
Results: The urine N-acetyl-beta-D-glucosaminidase activities in the patients with paraquat poisoning were higher than the corresponding values in the control participants (P<0.01); The prevalence rate of mortality was significantly higher in subjects with N-acetyl-beta-D-glucosaminidase activities ≥25 U/g Cr than in those N-acetyl-beta-D-glucosaminidase activities <25 Ulg Cr (34.4% vs 16.7%, P<0.01).
Conclusions: The urine N-acetyl-beta-D-glucosaminidase could be used as an early biomarker for acute kidney injury and predictor of mortality inpatients with acute paraquat intoxication.
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