The resistance of bioceramics against non-specific adsorption of serum proteins is critical for a wide range of biomedical applications. Some polysaccharides serve as natural protein-resistant molecules in extracellular matrices; however, the stable adhesion of polysaccharides to ceramic biomaterials in an aqueous solution is very challenging because chemical linkages at organic/inorganic interfaces are susceptible to hydrolytic degradation. Here, a catechol-grafted dextran, which strongly binds to titania (TiO2 ) in an aqueous milieu to effectively suppress cell adhesion through anti-fouling activity against non-specific protein adsorption, is introduced. Catechol is conjugated approximately to 6.7 mol% of glucose units of dextran via a carbamate ester linkage, corresponding to roughly three catechols per dextran chain having an average molecular weight of 6 kDa. Multivalent interactions of catechols with a titanium atom, enabled by the graft-type structure, provide a very stable coating of dextran on this inorganic surface. The adhesion of HeLa cells on the dextran-coated titania surface is reduced by 2.4-fold compared to that on a pristine titania surface. These results suggest that the graft-type incorporation of a small number of catechol moieties along a dextran backbone is an effective means of producing a stable anti-fouling interface on inorganic biomaterials in an aqueous environment.
Objective: Study of 2.6-di(propan-2-yl)phenol (2.6-di(P-2-yl)F) distribution nature in warm-blooded in case of fatal poisoning due to intragastric administration of the substance.
Background: Propolis is a natural substance produced by honeybees that has various biological properties including, anti-inflammatory, antioxidant and antimicrobial properties. Although previous studies have evaluated the antimicrobial effects of propolis in dentistry, its effects on dental pulp stem cell (DPSC) viability, migration, and differentiation are yet not well understood. The objective of this study was to investigate the effects of Chinese propolis on viability/proliferation, migration, differentiation and cytokine expression in DPSCs.
Poor aqueous solubility of crystalline active pharmaceutical ingredients (APIs) restricts their bioavailability. Amorphous solid dispersions with biocompatible polymer excipients offer a solution to overcome this problem, potentially enabling a broader use of many drug candidate molecules. This work addresses various aspects of the design of a suitable combination of an API and a polymer to form such a binary solid dispersion.
Department of Biomaterials, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
The present study was performed to synthesize eco-friendly nickel oxide nanoparticles (NiONPs) from the aqueous extract of Fissidens species (FS) and explore its biological activities. Phytochemicals, namely, alkaloids, flavonoids, sterols, tannins, proteins, carbohydrates and phenols, were present in the aqueous extract of Fissidens sp. The UV-Vis and FT-IR analyses of FS-NiONPs revealed a prominent peak at 392 nm, along with functional groups that facilitate the formation of FS-NiONPs.
Dimethyl sulfoxide (DMSO) is widely used as an adjuvant in dissolving insoluble compounds in an aqueous medium; however, it can induce significant molecular changes in cells. The possible damages may occur obeying a tissue-specific profile, and the effect on human apical papilla cells (hAPC) remains unknown. Therefore, this study aimed to evaluate DMSO effects on the viability and mineralization activity in hAPC cultures in vitro and to establish standards of maximum concentrations for its use in laboratory routines.
