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Multimodal artificial intelligence system for detecting a small esophageal high-grade squamous intraepithelial neoplasia: A case report.
World J Gastrointest Endosc
January 2025
Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Background: Recent advancements in artificial intelligence (AI) have significantly enhanced the capabilities of endoscopic-assisted diagnosis for gastrointestinal diseases. AI has shown great promise in clinical practice, particularly for diagnostic support, offering real-time insights into complex conditions such as esophageal squamous cell carcinoma.
Case Summary: In this study, we introduce a multimodal AI system that successfully identified and delineated a small and flat carcinoma during esophagogastroduodenoscopy, highlighting its potential for early detection of malignancies.
Insights in biomarkers complexity and routine clinical practice for the diagnosis of thyroid nodules and cancer.
PeerJ
January 2025
Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), i3S-Institute for Research & Innovation in Health, Porto, Portugal.
Background: The differential diagnosis between benign and malignant thyroid nodules continues to be a major challenge in clinical practice. The rising incidence of thyroid neoplasm and the low incidence of aggressive thyroid carcinoma, urges the exploration of strategies to improve the diagnostic accuracy in a pre-surgical phase, particularly for indeterminate nodules, and to prevent unnecessary surgeries. Only in 2022, the 5th WHO Classification of Endocrine and Neuroendocrine Tumors, and in 2023, the 3rd Bethesda System for Reporting Thyroid Cytopathology and the European Thyroid Association included biomarkers in their guidelines.
View Article and Find Full Text PDFIntegrated skin metabolomics and network pharmacology to explore the mechanisms of Goupi Plaster for treating knee osteoarthritis.
J Tradit Complement Med
November 2024
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese, Harbin, 150040, China.
Background And Aim: Goupi Plaster (GP) is topical traditional Chinese medicine preparation. It has been used to treat Knee Osteoarthritis (KOA) in clinical practice of traditional Chinese medicine (TCM). However, the mechanisms of GP relieve KOA are poorly understood.
View Article and Find Full Text PDFMicroRNA-155 as Biomarker and Its Diagnostic Value in Breast Cancer: A Systematic Review.
World J Oncol
February 2025
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
The investigation of microRNAs (miRNAs) for the purpose of identifying biomarkers and new treatments for breast cancer has been gaining traction from scientists in recent years. Of all the miRNAs, miR-155 has been reportedly involved in breast cancer development as it regulates various cellular processes such as glucose uptake, proliferation, metastasis, and migration. Various efforts have been done towards researching miR-155 as a biomarker in breast cancer; however, the results were varied.
View Article and Find Full Text PDFEvaluating Infertility Through Diagnostic Hysterolaparoscopy: A Prospective Study.
Cureus
December 2024
Obstetrics and Gynaecology, Dr. D Y Patil Medical College, Hospital and Research Centre, Dr. D Y Patil Vidyapeeth (Deemed to be University) Pimpri, Pune, IND.
Background Infertility affects a significant proportion of reproductive-age couples globally, with diverse causes. Diagnostic hystero-laparoscopy (DHL) is emerging as a preferred diagnostic tool for evaluating infertility, combining laparoscopy and hysteroscopy for comprehensive assessment. Objective The primary objective of this prospective study was to evaluate the diagnostic accuracy and clinical utility of DHL in identifying the causes of infertility in women.
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