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Formaldehyde exposure and leukemia: critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility. | LitMetric

AI Article Synopsis

  • - A study by Zhang et al. (2010) suggested that aneuploidy (abnormal number of chromosomes) in circulating stem cells could explain formaldehyde's impact on bone marrow, but a critical review raised doubts about these findings.
  • - A reanalysis indicated that factors other than formaldehyde may have affected the results, and the study's claims about analyzing a sufficient number of cells were not properly followed.
  • - The assays used did not accurately assess the primitive cells linked to leukemia, leading to the conclusion that the observed aneuploidy likely occurred during lab culture rather than in living organisms, undermining a causal link between formaldehyde and blood cancers.

Article Abstract

A recent study (Zhang et al., 2010) has provided results attributed to aneuploidy in circulating stem cells that has been characterized as providing potential support for proposed mechanisms for formaldehyde to impact bone marrow. A critical review of the study, as well as a reanalysis of the underlying data, was performed and the results of this reanalysis suggested factors other than formaldehyde exposure may have contributed to the effects reported. In addition, although the authors stated in their paper that "all scorable metaphase spreads on each slide were analyzed, and a minimum of 150 cells per subject was scored," this protocol was not followed. In fact, the protocol to evaluate the presence of monosomy 7 or trisomy 8 was followed for three or less samples in exposed workers and six or less samples in non-exposed workers. In addition, the assays used (CFU-GM) do not actually measure the proposed events in primitive cells involved in the development of acute myeloid leukemia. Evaluation of these data indicates that the aneuploidy measured could not have arisen in vivo, but rather arose during in vitro culture. The results of our critical review and reanalysis of the data, in combination with recent toxicological and mechanistic studies, do not support a mechanism for a causal association between formaldehyde exposure and myeloid or lymphoid malignancies.

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Source
http://dx.doi.org/10.3109/10408444.2013.818618DOI Listing

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