Histomorphometrical and ultrastructural study of the effects of carbendazim on the magnum of the Japanese quail (Coturnix coturnix japonica).

Onderstepoort J Vet Res

Department of Anatomy and Physiology, University of Pretoria, South Africa and Department of Veterinary Anatomy, Sokoine University of Agriculture, Tanzania.

Published: July 2013

The study investigated the effect of various doses of carbendazim on the morphology of the magnum of the Japanese quail. No morphological changes were observed in the magnum in birds treated with carbendazim at doses of 25 mg/kg and 100 mg/kg bodyweight. A carbendazim dose of 400 mg/kg bodyweight was the lowest dose which caused morphological changes in the magnum. Histologically, carbendazim caused pyknosis and glandular atrophy in the magnum mucosa. Carbendazim also caused significant decreases in the height of the mucosal folds, epithelial height, glandular width and glandular luminal diameter at 400 mg/kg and 800 mg/kg (p < 0.05). At ultrastructural level, dose-dependent deciliation was observed. Pyknotic nuclei, dilated cisternae of rough endoplasmic reticulum, swollen mitochondria, numerous vacuoles and lysosomes in the luminal and glandular epithelia were identified. The observed degenerative changes could be due to cytoskeletal disruption caused by carbendazim toxicity. Degeneration of the luminal and glandular cells in the magnum pose a potential threat to the egg production and reproduction of exposed birds.

Download full-text PDF

Source
http://dx.doi.org/10.4102/ojvr.v80i1.579DOI Listing

Publication Analysis

Top Keywords

magnum japanese
8
japanese quail
8
morphological changes
8
mg/kg bodyweight
8
400 mg/kg
8
carbendazim caused
8
luminal glandular
8
carbendazim
7
magnum
6
mg/kg
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!