Context: Quantification of circulating microRNAs (miRNAs) has recently become feasible and reliable, with most efforts focusing on miRNAs overexpressed by cancer cells.
Objective: Identification of a characteristic circulating miRNAs profile in melanoma patients.
Methods: We conducted a pilot study comprised of unbiased qPCR comparison of serum miRNA profiles between metastatic melanoma patients and healthy donors.
Results: Loss of two normal serum-miRNAs, miR-29c and miR-324-3p, is highly indicative of metastatic melanoma. Hierarchical clustering analysis supported the results and clearly distinguished melanoma patients from healthy donors, metastatic colon and renal cancer patients.
Discussion And Conclusions: This approach is independent of tumor heterogeneity and is expected to have superior biomarker performances.
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| http://dx.doi.org/10.3109/1354750X.2013.816777 | DOI Listing |
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