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Pharmacotherapy response and regional cerebral blood flow characteristics in patients with obsessive-compulsive disorder. | LitMetric

AI Article Synopsis

  • The study investigates how pre-treatment regional cerebral blood flow (rCBF) in patients with OCD correlates with their response to pharmacotherapy.
  • Using SPECT imaging, researchers compared rCBF in 30 OCD patients and 30 healthy controls, tracking their treatment responses over 24 weeks.
  • Results showed that higher rCBF in certain forebrain areas was linked to better responses to SSRIs, while changes in rCBF in posterior brain regions were noted in those treated with SSRIs plus quetiapine, suggesting rCBF patterns may help predict treatment efficacy.

Article Abstract

Objective: To analyze the correlation between the pharmacotherapy response and the characteristics of the pre-treatment regional cerebral blood flow (rCBF) in patients with obsessive-compulsive disorder (OCD).

Methods: Single-photon emission-computed tomography (SPECT) was used to determine the pre-treatment rCBF in 30 OCD patients and 30 normal controls. Based on their clinical remission response, the subjects were divided into two groups: selective serotonin reuptake inhibitors (SSRIs) and SSRIs plus quetiapine. The subjects with clinical remission response were identified after treatment for a period of 24 weeks, and the rCBF imaging data were processed using statistical parametric mapping (SPM) software with two-sample Z-tests.

Results: Nineteen OCD patients who achieved clinical remission were included in the study. Increased rCBF in forebrain regions, including the frontal lobe, cingulate gyrus, hypothalamus, and basal ganglia, was found in 11 responders to SSRIs compared to normal control patients. The eight SSRI plus quetiapine responders exhibited a decrease in rCBF within posterior brain regions, including the parietal lobe, cerebellar vermis, and occipital lobe, and an increase in rCBF in the frontal lobe, thalamus, basal ganglia, and cerebellum tonsil compared to normal control patients.

Conclusions: The characteristics of increased rCBF in forebrain regions and decreased rCBF in posterior brain regions before treatment of OCD patients was a potentially predictor of treatment response to guide treatment options.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733897PMC
http://dx.doi.org/10.1186/1744-9081-9-31DOI Listing

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