AI Article Synopsis
- Type 1 renal tubular acidosis (RTA) is a kidney disorder that affects acid handling and can sometimes lead to symptoms like weakness, as seen in a young male patient who experienced sudden muscle weakness and leg swelling.
- Diagnostic tests indicated hypokalemia, metabolic acidosis, and nephrotic syndrome, leading to the identification of normal anion gap metabolic acidosis along with distal RTA.
- The patient's condition improved with potassium supplements, and treatment with an ACE inhibitor helped normalize potassium levels and reduce protein in urine, highlighting the rare combination of distal RTA and membranous nephropathy.
Article Abstract
Type 1 renal tubular acidosis (RTA), or distal RTA (dRTA), is a disorder of renal tubular acidification, which is generally asymptomatic but may rarely present as hypokalemic paralysis. Here, we report the case of a young male who presented with sudden onset weakness of all 4 limbs and a 2-month history of swelling of the legs. An investigation revealed hypokalemia, metabolic acidosis, and nephrotic syndrome. Additional analyses revealed normal anion gap metabolic acidosis with a positive urine anion gap and dRTA. Renal biopsy showed evidence of membranous nephropathy (MN). The patient's weakness improved with potassium supplements. Normalization of the serum potassium level and disappearance of proteinuria were established with an ACE inhibitor and potassium supplementation. This case is an unusual combination of dRTA with MN coupled with the rare presenting symptoms of hypokalemic paralysis and medullary nephrocalcinosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721128 | PMC |
| http://dx.doi.org/10.1159/000353768 | DOI Listing |
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