AI Article Synopsis
- Cardiac amyloidosis is a rare condition where abnormal proteins deposit in the heart, leading to heart failure due to restrictive cardiomyopathy.
- A specific case highlights how cardiac amyloidosis can reveal underlying multiple myeloma in patients without prior heart issues.
- Key signs to identify it include unexplained heart failure symptoms, specific ECG findings, preserved ejection fraction, and unique echocardiogram texture, with a focus on vigilant monitoring due to high mortality risk.
Article Abstract
Cardiac amyloidosis or amyloid cardiomyopathy is a rare disorder characterised by extracellular deposition of insoluble polymers composed of low-molecular-weight subunit proteins within the myocardium. This often results in an infiltrative cardiomyopathy with restrictive pathophysiology, leading to progressive heart failure. In this report, we present an interesting case of cardiac amyloidosis that eventually led to the diagnosis of underlying multiple myeloma in a patient with no previous cardiac history. Cardiac amyloidosis should be suspected in patients with unexplained congestive heart-failure symptoms accompanied by low-voltage complexes on ECG, preserved ejection fraction with asymmetric ventricular hypertrophy and abnormal myocardial texture, described as 'granular sparkling' on echocardiogram. Patients with cardiac amyloidosis should be closely monitored as mortality remains high, despite advances in treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736195 | PMC |
| http://dx.doi.org/10.1136/bcr-2012-008113 | DOI Listing |
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