Objectives: To calculate the incidence of nondiagnostic (ND) colorectal (CR) polyp cases in which deeper tissue sectioning rendered new diagnostic information--particularly adenomas--in 2 laboratories staffed by the same pathologists.
Methods: After initial diagnosis, 100 ND CR polyps from each laboratory were reexamined with 3 deeper levels to establish rates of diagnostic conversion based on biopsy specimen location and original observation(s).
Results: Deeper sectioning rendered new diagnostic information in 43 (21.5%) of 200 biopsy specimens and specifically adenomas in 16 (8.0%) of 200 biopsy specimens.
Conclusions: These results support routine ordering of deeper levels on ND CR polyps to improve adenoma detection rates, especially those cases without any histologic abnormality. If another biopsy in the same case already is adenomatous, examination of deeper levels may not be necessary, as it may not have any significant effect on the clinical management of the patient.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1309/AJCPPXU66QZAZNYN | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Natural sampling and aliasing of marine geochemical signals.
Sci Rep
January 2025
Westchase Software, Houston, TX, 77063, USA.
It is well known that the sedimentary rock record is both incomplete and biased by spatially highly variable rates of sedimentation. Without absolute age constraints of sufficient resolution, the temporal correlation of spatially disjunct records is therefore problematic and uncertain, but these effects have rarely been analysed quantitatively using signal processing methods. Here we use a computational process model to illustrate and analyse how spatial and temporal geochemical records can be biased by the inherent, heterogenous processes of marine sedimentation and preservation.
View Article and Find Full Text PDFExpression profiles of miR-101-3p and miR-431-5p as potential diagnostic biomarkers for rheumatoid arthritis.
Sci Rep
January 2025
Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, P. O. Box 77, Giza, Egypt.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent inflammation of the synovial joints, leading to cartilage and bone destruction. This study aimed to evaluate the diagnostic utility of specific microRNAs (miRNAs) as potential biomarkers for RA. The study was conducted on 60 patients with RA disease along with 20 control participants.
View Article and Find Full Text PDFRecent advances in nanoarchitectonics of two-dimensional nanomaterials for dental biosensing and drug delivery.
Adv Colloid Interface Sci
December 2024
Department of Periodontology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing 210008, China. Electronic address:
Two-dimensional (2D) nanoarchitectonics involve the creation of functional material assemblies and structures at the nanoscopic level by combining and organizing nanoscale components through various strategies, such as chemical and physical reforming, atomic and molecular manipulation, and self-assembly. Significant advancements have been made in the field, with the goal of producing functional materials from these nanoscale components. 2D nanomaterials, in particular, have gained substantial attention due to their large surface areas which are ideal for numerous surface-active applications.
View Article and Find Full Text PDFregionalpcs improve discovery of DNA methylation associations with complex traits.
Nat Commun
January 2025
Department of Biomedical Data Science, Stanford University, Stanford, CA, USA.
We have developed the regionalpcs method, an approach for summarizing gene-level methylation. regionalpcs addresses the challenge of deciphering complex epigenetic mechanisms in diseases like Alzheimer's disease. In contrast to averaging, regionalpcs uses principal components analysis to capture complex methylation patterns across gene regions.
View Article and Find Full Text PDFThe evolution of cooperation in spatial public goods game with tolerant punishment based on reputation threshold.
Chaos
January 2025
Department of Computer Science and A.I. Andalusian Research Institute DaSCI "Data Science and Computational Intelligence, " University of Granada, 18071 Granada, Spain.
Reputation and punishment are significant guidelines for regulating individual behavior in human society, and those with a good reputation are more likely to be imitated by others. In addition, society imposes varying degrees of punishment for behaviors that harm the interests of groups with different reputations. However, conventional pairwise interaction rules and the punishment mechanism overlook this aspect.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!