Objectives: To investigate whether discriminating the classic perinuclear antineutrophil cytoplasmic antibody (P-ANCA) pattern from atypical P-ANCA and uninterpretable patterns improves the diagnostic utility of ANCA testing.
Methods: All ANCA requests (n = 3,544) referred to Pathology Queensland were analyzed prospectively over 4 months for P-ANCA pattern subtypes and myeloperoxidase (MPO)-ANCA/PR3-ANCA results and correlated with clinical, laboratory, and radiologic evidence of necrotizing small vessel vasculitis.
Results: Of the 436 perinuclear immunofluorescence-positive samples, 45 were classic P-ANCA, 163 were atypical P-ANCA, and 228 were antinuclear antibodies/uninterpretable. The classic P-ANCA pattern had a significantly stronger association with vasculitis (30/45) than atypical P-ANCA (2/163) (P <.0001) or ANA/uninterpretable patterns (8/228) (P <.0001). The combination of a classic P-ANCA pattern and positive MPO-ANCA/PR3-ANCA result was also more strongly associated with vasculitis than a positive MPO-ANCA/PR3-ANCA result in isolation (P = .003).
Conclusions: This study demonstrates that reporting different P-ANCA patterns (including ANA/uninterpretable patterns) provides additional diagnostic information to MPO-ANCA/PR3-ANCA results.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1309/AJCP4Y8ADMKOSCXV | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical Profiles, Survival, and Lung Function Outcomes in ANCA-Associated Interstitial Lung Disease: An Observational Study.
J Clin Med
January 2025
Rheumatology Department, Hospital Universitario de La Princesa, IIS-Princesa, 28006 Madrid, Spain.
: Anti-neutrophil cytoplasmic antibodies (ANCAs) have been found in interstitial lung disease (ILD) in recent years, although its impact on ILD prognosis is less known. To date, ANCAs are not included in the interstitial pneumonia with autoimmune features (IPAF) definition criteria. Therefore, ANCA-ILD, in the absence of known ANCA-associated vasculitis (AAV), could be underdiagnosed.
View Article and Find Full Text PDFHistory of antineutrophil cytoplasmic autoantibodies : Milestones in rheumatology.
Z Rheumatol
December 2024
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are autoimmune inflammatory small-vessel disorders with potentially life-threatening organ manifestations. Recent disease definitions and classification criteria allow distinction between granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis (EGPA), and non-granulomatous microscopic polyangiitis (MPA). The discovery of ANCA-autoantibodies directed against proteolytic enzymes of neutrophil granules-has enabled earlier diagnosis of AAV and paved the way to stage-adapted treatments.
View Article and Find Full Text PDFClinical features, radiological findings and prognosis of microscopic polyangiitis with interstitial lung disease: a retrospective matched control study.
BMC Pulm Med
December 2024
Department of Respiratory, Ningbo Zhenhai People's Hospital (Ningbo No. 7 Hospital), No. 718, Nan'er West Road, Luotuo Street, Zhenhai, Ningbo, Zhejiang, China.
Background: The association between interstitial lung disease (ILD) and microscopic polyangiitis (MPA) has received increasing attention in recent years. However, there are still no studies comparing clinical characteristics and prognoses between MPA-ILD patients and patients with ANCA-negative ILDs. Therefore, the purpose of this study was to analyse a group of patients presenting MPA-ILD matched with patients exhibiting ANCA-negative ILDs to identify differences in their clinical characteristics and survival.
View Article and Find Full Text PDFSystemic Vasculitis Post-COVID-19: A Case Report.
Cureus
October 2024
Internal Medicine, Jalalabad Ragib-Rabeya Medical College, Sylhet, BGD.
Article Synopsis
- Vasculitis is a potential complication of COVID-19, where the virus can trigger or worsen autoimmune diseases like systemic vasculitis.
- The case of an elderly patient with multiple health issues highlighted the connection, as doctors diagnosed vasculitis due to renal function decline and positive antinuclear antibodies.
- A kidney biopsy confirmed focal necrotizing and crescentic glomerulonephritis, emphasizing the need for awareness of COVID-19 related complications and a broad differential diagnosis in recovering patients.
Clinical characteristics and prognostic factors for MPO-ANCA positive interstitial lung disease: A comparative study of ANCA associated vasculitis (AAV)-ILD and pulmonary limited vasculitis.
Respir Investig
January 2025
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.
Article Synopsis
- This study investigates the impact of microscopic polyangiitis (MPA) on patients with interstitial lung disease (ILD), focusing on their clinical characteristics and treatment outcomes.
- Within a sample of 114 patients, those diagnosed with ANCA-associated vasculitis with ILD (AAV-ILD) were found to have better survival rates and treatment responses compared to those with pulmonary limited vasculitis (PLV).
- The findings emphasize the critical role of accurate diagnosis and treatment planning, suggesting that HRCT imaging and corticosteroid response are vital for understanding patient prognosis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!