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Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker, further replication studies are required. The objective of this study was to investigate associations between IFSH and CSVD, and their potential repercussions, i.
View Article and Find Full Text PDFAssessment of glymphatic function and white matter integrity in children with autism using multi-parametric MRI and machine learning.
Eur Radiol
January 2025
Department of Radiology, Affiliated Children's Hospital of Jiangnan University, Wuxi, China.
Objectives: To assess glymphatic function and white matter integrity in children with autism spectrum disorder (ASD) using multi-parametric MRI, combined with machine learning to evaluate ASD detection performance.
Materials And Methods: This retrospective study collected data from 110 children with ASD (80 exploratory, 43 validation) and 68 typically developing children (50 exploratory, 18 validation) from two centers. The automated diffusion tensor imaging along the perivascular space (aDTI-ALPS), fractional anisotropy (FA), cerebrospinal fluid volume, and perivascular space (PVS) volume indices were extracted from DTI, three-dimensional T1-weighted, and T2-weighted images.
From bench to bedside: US-Japan Collaborative Workshop on the NVU.
J Physiol Sci
January 2025
Department of Neurology, Keio University School of Medicine, Tokyo, Japan.
The joint workshop between U.S. and Japanese researchers, supported by The U.
View Article and Find Full Text PDFAssociations of ventriculomegaly and white matter hyperintensities with glymphatic dysfunction in idiopathic normal pressure hydrocephalus.
Eur Radiol
January 2025
Department of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Objectives: To investigate glymphatic function in idiopathic normal pressure hydrocephalus (iNPH) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method and to explore the associations of ALPS index with ventriculomegaly and white matter hyperintensities (WMH).
Materials And Methods: This study included 41 patients with iNPH and 40 age- and sex-matched normal controls (NCs). All participants underwent brain MRI.
Perivascular enhancement pattern: Identification, Diagnostic spectrum and Practical approach - A pictorial review.
J Neuroradiol
January 2025
Department of Neuroradiology, Kremlin-Bicêtre Hospital, Le Kremlin-Bicêtre, France.
Perivascular spaces (PVS) are fluid-filled structures that form the immediate peripheral environment of small cerebral vessels. They are a central component of the glymphatic system, which plays a crucial role in maintaining cerebral homeostasis. Their involvement in central nervous system diseases is currently a major focus of research, particularly in neuroimaging.
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