A complex clinical-hormonal examination was conducted in 140 women most of whom suffered from habitual abortion and hyperandrogenicity (HA). Based on the clinical findings, determination of the basal hormone level, and functional tests the patients were divided into 3 groups: 1) patients with predominantly adrenal HA (30 per cent); 2) patients with mainly ovarian HA (12.1 per cent), and 3) patients with an abnormally high level of androgens of ovarian-adrenal origin (57.9 per cent). The peculiarities of the clinical and hormonal parameters in patients of the three groups as well as the pathogenetic therapy aimed at preparation for pregnancy prolongation to term and birth of a viable neonate.
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Front Antibiot
September 2024
Research and Education, Clinical Research Education and Management Services (CREAMS), Lilongwe, Malawi.
Background: Childhood remains a vulnerable period and a key determiner for adult health. Various illnesses experienced by children in their early years determine future performance and contribution to society. Acute and chronic infectious diseases, undernutrition, and early childhood non-communicable diseases have greatly been linked to intellectual disability, poor childhood development, increased morbidity, and household and healthcare economic costs.
View Article and Find Full Text PDFBMJ Open
December 2024
Division of Research, Kaiser Permanente, Pleasanton, California, USA.
Objectives: The US Preventive Services Task Force recommends screening of adults aged 35-70 with a body mass index ≥25 kg/m for type 2 diabetes and referral of individuals who screen positive for pre-diabetes to evidence-based prevention strategies. The diabetes burden in the USA is predicted to triple by 2060 necessitating strategic diabetes prevention efforts, particularly in areas of highest need. This study aimed to identify pre-diabetes hotspots using geospatial mapping to inform targeted diabetes prevention strategies.
View Article and Find Full Text PDFBMJ Open
December 2024
Clinical Medicine, School of Medicine and Population Health, The University of Sheffield, Sheffield, UK
Introduction: Cortisol is an essential stress hormone and failure of its production, known as adrenal insufficiency (AI), is associated with significant mortality due to adrenal crisis. The Short Synacthen Test (SST) is the current diagnostic test of choice for AI, but it is both invasive and resource intensive. Globally, there is an unmet need for a non-invasive, cost-effective test.
View Article and Find Full Text PDFAustralas J Dermatol
January 2025
The Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia.
Background: Recent Australian trends indicate that shave biopsies for diagnosing lesions suspicious of melanoma are increasing, yet reasons for this remain relatively unknown. We sought to understand which factors influence Australian clinicians' use of shave biopsy for managing thin lesions suspicious of melanoma in sites of low cosmetic sensitivity.
Methods: We used a convergent, exploratory mixed-methods design, with a cross-sectional online survey (n = 59) and semi-structured qualitative interviews (n = 15).
Liver Int
February 2025
Sorbonne Université, Service Médecine Interne, Centre de référence des maladies autoinflammatoires et des amyloses (CEREMAIA), Assistance Publique des hôpitaux de Paris, Hôpital Tenon, Paris, France.
Background: Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, associated with MEFV mutations. FMF patients can experience liver involvement, potentially leading to cirrhosis.
Objectives: This study aimed to evaluate liver involvement in FMF patients at a French tertiary centre for adult FMF.
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