Antitubercular drug development: current status and research strategies.

Mini Rev Med Chem

Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad-382481, Gujarat, India.

Published: October 2013

AI Article Synopsis

  • Recent research and innovative strategies are being implemented to discover and create new drugs for tuberculosis, a major global health challenge.
  • Approximately nine million new tuberculosis cases occur annually, with nearly two million deaths, highlighting the urgent need for new antitubercular medications.
  • The current discussion includes the status of tuberculosis, advancements in drug development, new molecular targets, novel agents in various development stages, and efforts to create new lead compounds with different pharmacophores.

Article Abstract

Recent developments and novel research strategies are adopted widely to discover and develop the new drugs to treat tuberculosis. New antitubercular drugs are urgently needed because tuberculosis remains a global health problem as around nine million new cases are estimated each year with almost two million fatalities. It states the impact and outcomes that have made a significant effect in antitubercular drug development. We are presenting current status of tuberculosis, antitubercular drug development, novel molecular targets, novel agents in clinical and pre-clinical development and some efforts that are being made in the development of novel molecules based on different pharmacophores as lead compounds and recent strategies.

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Source
http://dx.doi.org/10.2174/13895575113139990076DOI Listing

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