Parathryoid hormone related peptide causing hypercalcaemia in a patient with hepatocellular carcinoma.

J Pak Med Assoc

Department of Gastroenterology and Hepatology, Crosshouse Hospital, Kilmarnock, UK.

Published: February 2013

The incidence of hepatocellular carcinoma (HCC) is increasing. In addition, its presentation without bony metastasis as a part of paraneoplastic syndrome is recognised but uncommon. This unusual presentation of HCC is highlighted in the case of a 63 years old lady, who presented with lethargy and tiredness and hypercalcaemia due to secretion of parathryoid hormone related peptide (PTHrP). Further imaging showed 11 cm hepatic mass, with normal alpha fetoprotein. She underwent partial hepatectomy and is doing well since then. Malignant hypercalcaemia is thought to arise from the secretion of PTHrP which is synthesised by tumour cells and has a similar action to parathyroid hormone. Early recognition of this uncommon condition can lead to complete cure as seen in our patient.

Download full-text PDF

Source

Publication Analysis

Top Keywords

parathryoid hormone
8
hormone peptide
8
hepatocellular carcinoma
8
peptide causing
4
causing hypercalcaemia
4
hypercalcaemia patient
4
patient hepatocellular
4
carcinoma incidence
4
incidence hepatocellular
4
carcinoma hcc
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!