Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jcph.135 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Trimethylamine N-oxide in cardiovascular disease: Pathophysiology and the potential role of statins.
Life Sci
January 2025
Department of Internal Medicine, Metropolitan Hospital Center, New York, NY, USA. Electronic address:
Cardiovascular diseases are one of the leading causes of mortality and morbidity worldwide, with the total number of cases increasing to 523 million in 2019. Despite the advent of new drugs, cardiovascular mortality has increased at an alarming rate of 53.7 % from 12.
View Article and Find Full Text PDF[Identification of meldonium in the urine of volunteers using high-performance liquid chromatography-tandem mass spectrometry after consumption of milk of cows treated with a preventive course of the veterinary drug Emidonol].
Vopr Pitan
November 2024
Federal Research Centre for Nutrition, Biotechnology and Food Safety, 109240, Moscow, Russian Federation.
Emidonol is a Russian antioxidant drug, widely used in veterinary medicine both for prophylactic purposes and under pathological conditions associated with oxygen deficiency. The product of its biotransformation in animals is meldonium, which is a metabolic modulator and has been included on the Prohibited List by the World Anti-Doping Agency (WADA) since 2016. In the presented research, volunteers once consumed samples of milk from cows that had undergone a 15-day course of the veterinary drug Emidonol® 10%, obtained from one of the farms in the Moscow region.
View Article and Find Full Text PDFMeldonium Supplementation in Professional Athletes: Career Destroyer or Lifesaver?
Cureus
July 2024
Biochemistry, Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu Mureș, ROU.
Meldonium is a substance with known anti-anginal effects demonstrated by numerous studies and human clinical trials; however, it does not possess marketing authorization within the European Union, only in ex-Soviet republics. Since 2016, meldonium has been included by the World Anti-doping Agency (WADA) on the S4 list of metabolic modulators. In performance athletes, meldonium is now considered a doping agent due to its capacity to decrease lactate production during and after exercise, its capability to enhance the storage and utilization of glycogen, and its protective action against oxidative stress.
View Article and Find Full Text PDFMitochondrial targeted antioxidants as potential therapy for huntington's disease.
Pharmacol Rep
August 2024
Department of Pharmacology, Central University of Punjab, Ghudda, Bathinda, Punjab, 151401, India.
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expansion in CAG repeat on huntington (Htt) gene, leading to a degeneration of GABAergic medium spiny neurons (MSNs) in the striatum, resulting in the generation of reactive oxygen species, and decrease antioxidant activity. These pathophysiological alterations impair mitochondrial functions, leading to an increase in involuntary hyperkinetic movement. However, researchers investigated the neuroprotective effect of antioxidants using various animal models.
View Article and Find Full Text PDFMeldonium Inhibits Cell Motility and Wound-Healing in Trabecular Meshwork Cells and Scleral Fibroblasts: Possible Applications in Glaucoma.
Pharmaceuticals (Basel)
April 2023
Fidia Pharmaceuticals, Research Center, 95123 Catania, Italy.
Meldonium (MID) is a synthetic drug designed to decrease the availability of L-carnitine-a main player in mitochondrial energy generation-thus modulating the cell pathways of energy metabolism. Its clinical effects are mostly evident in blood vessels during ischemic events, when the hyperproduction of endogenous carnitine enhances cell metabolic activities, leading to increased oxidative stress and apoptosis. MID has shown vaso-protective effects in model systems of endothelial dysfunction induced by high glucose or by hypertension.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!