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Molecular biology aims to understand the details of life by focusing closely on biopolymers-DNAs, RNAs, and proteins-and how they interact with one another. Advances in this field have enabled dazzling achievements in virtually all areas of biological, biomedical, and clinical sciences. As we draw near to the conclusion of Cell's 50 anniversary, we celebrate the wonders of molecular biology and look ahead to the exciting path forward for a branch of science that is driven by curiosity and has always been an integral part of the journal.
View Article and Find Full Text PDFForgotten Gems: Exploring the Untapped Benefits of Underutilized Legumes in Agriculture, Nutrition, and Environmental Sustainability.
Plants (Basel)
April 2024
Biopolymer Analytics, Institute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany.
In an era dominated by conventional agricultural practices, underutilized legumes termed "Forgotten Gems" represent a reservoir of untapped benefits with the unique opportunity to diversify agricultural landscapes and enhance global food systems. Underutilized crops are resistant to abiotic environmental conditions such as drought and adapt better to harsh soil and climatic conditions. Underutilized legumes are high in protein and secondary metabolites, highlighting their role in providing critical nutrients and correcting nutritional inadequacies.
View Article and Find Full Text PDFFunctionalized chitosan hydrogel promotes osseointegration at the interface of3D printed titanium alloy scaffolds.
Int J Biol Macromol
May 2024
Medical Center of Hip, Luoyang Orthopedic-Traumatological Hospital, Luoyang 471000, PR China. Electronic address:
Article Synopsis
- - Autogenous bone transplantation faces challenges due to limited donor availability and complications from harvesting, leading researchers to explore bio-inspired scaffolds as alternatives.
- - A promising solution involves using 3D-printed titanium alloy scaffolds paired with thermosensitive chitosan hydrogel, which can transition from liquid to solid at body temperature for enhanced bone tissue engineering.
- - The system enables the localized delivery of icariin (ICA), promoting bone marrow mesenchymal stem cell differentiation and demonstrating improved bone regeneration and integration in laboratory studies.
Natural herb wormwood-based microneedle array for wound healing.
Drug Deliv Transl Res
September 2024
College of Pharmaceutical Science, Zhejiang University of Technology, #18 Chaowang Road, Hangzhou, 310014, China.
Artemisia argyi, commonly known as wormwood, is a traditional Chinese herbal food and medicine celebrated for its notable antibacterial and anti-inflammatory properties. This study explores a novel delivery method for wormwood, aiming for more convenient and versatile applications. Specifically, we present the first investigation into combining wormwood with microstructures to create a microneedle (MN) patch for wound healing.
View Article and Find Full Text PDFFrom waste to health-supporting molecules: biosynthesis of natural products from lignin-, plastic- and seaweed-based monomers using metabolically engineered Streptomyces lividans.
Microb Cell Fact
December 2023
Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Background: Transforming waste and nonfood materials into bulk biofuels and chemicals represents a major stride in creating a sustainable bioindustry to optimize the use of resources while reducing environmental footprint. However, despite these advancements, the production of high-value natural products often continues to depend on the use of first-generation substrates, underscoring the intricate processes and specific requirements of their biosyntheses. This is also true for Streptomyces lividans, a renowned host organism celebrated for its capacity to produce a wide array of natural products, which is attributed to its genetic versatility and potent secondary metabolic activity.
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