AI Article Synopsis
- The study aimed to preliminarily evaluate the effectiveness of zonisamide for treating bulimia nervosa over a 12-week open-label trial.
- Zonisamide significantly reduced binge-purge episode frequency and associated behaviors, showing improvement in clinical severity and depressive symptoms, while not affecting weight.
- Although effective, the trial faced a high discontinuation rate, indicating potential challenges in treatment adherence.
Article Abstract
Objective: To assess preliminarily the effectiveness of zonisamide in bulimia nervosa.
Method: This was an open-label, prospective, 12-week, flexible dose study of zonisamide in bulimia nervosa. The primary outcome was binge-purge episode frequency.
Results: Twelve individuals received zonisamide, 10 completed at least one post-baseline evaluation, and six completed the study. Mean dose at endpoint was 420 (SD = 215) mg/day. Zonisamide was associated with significant reductions in frequency of binge-purge episodes and binge-purge days as well as measures of binge eating behavior, purging behavior, clinical severity, obsessive-compulsive features, and depressive symptoms. Weight was unchanged.
Discussion: In this open-label trial, zonisamide was effective in bulimia nervosa, but associated with a high discontinuation rate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/eat.22159 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuromodulatory techniques in eating disorders: From electroconvulsive therapy to transcranial magnetic stimulation and beyond: A mixed method systematic meta-review.
Psychiatry Res
December 2024
Eating Disorders Unit, Department of Neuroscience "Rita Levi Montalcini", University of Turin, via Cherasco 15, 10126, Turin, Italy. Electronic address:
Background: Psychosocial and pharmacological interventions can effectively treat eating disorders (EDs), but improvements are often short-term and modest. Neuromodulation, altering nerve activity through targeted neurological stimulation, is an emerging intervention in neuropsychiatric disorders. This meta-review synthesizes evidence on neuromodulatory techniques in ED patients, identifying research gaps and future directions.
View Article and Find Full Text PDFEating- and Weight-Related Disorders in the Armed Forces.
Metabolites
December 2024
Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Background/objectives: Like in the general population, the prevalences of eating- and weight-related health issues in the armed forces are increasing. Relevant medical conditions include the eating disorders (EDs) anorexia nervosa, bulimia nervosa, binge eating disorder, and avoidant restrictive food intake disorder (ARFID), as well as body dysmorphic disorder, muscle dysmorphia, and the relative energy deficiency in sport (RED-S) syndrome.
Methods: We performed a narrative literature review on eating- and weight-related disorders in the armed forces.
Eating Disorders in Adolescents and Young Adults: A Program Evaluation of a Canadian Eating Disorder Treatment Program.
Cureus
November 2024
Health Services Management, Ted Rogers School of Management, Toronto Metropolitan University, Toronto, CAN.
Background: Current treatments for adolescents with eating disorders (ED) show limited effectiveness, emphasizing the need for enhanced therapeutic approaches. Cognitive behavioral therapy (CBT) has emerged as a potential alternative. A derivative of this approach, group cognitive behavioral therapy (G-CBT), has been shown to reduce treatment costs and increase treatment accessibility when compared to CBT.
View Article and Find Full Text PDFEnhancing assessment for eating disorders: the impact of a podcast-based pre-treatment psychoeducation intervention.
Eat Disord
December 2024
Department of Psychology, University of Sheffield, Sheffield, UK.
This study reports the outcome of a low intensity pre-treatment intervention (a guided e-health podcast) for patients with anorexia nervosa and bulimia nervosa, delivered between assessment and the start of the full outpatient treatment programme. A case series design was used. A total of 254 patients at a specialist eating disorder service were offered a pre-treatment three-week psychoeducational intervention (Keeping Myself Safe; KMS), and 203 undertook the intervention.
View Article and Find Full Text PDFDo empirically-derived personality subtypes relate to cognitive inflexibility in anorexia nervosa and bulimia nervosa?
J Eat Disord
December 2024
Department of Psychiatry and Behavioral Neuroscience, University of Chicago, 5841 S. Maryland Avenue, MC 3077, Chicago, IL, 60637, USA.
Background: Accruing evidence suggests that personality-based approaches to eating disorder classification may offer several advantages over current diagnostic models, with prior research consistently identifying three personality-based groups characterized by either (1) high levels of impulsivity and dysregulation (termed the "undercontrolled" group), (2) high levels of rigidity and avoidance (termed the "overcontrolled" group), or (3) relatively normative levels of personality functioning (termed the "low psychopathology" group). Cognitive inflexibility (i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!