Aim: To determine justifiability of oral glucose tolerance test (OGTT) in non diabetic patients with metabolic syndrome (MetS).
Methods: It was included 398 patients attended to Outpatient Clinics of Sisli Etfal Training and Research Hospital. Eligible patients were assigned as patients with MetS according to International Diabetes Federation (IDF) criteria.
Results: After OGTT, there were 7 (2%) diabetic patients, 119 (30%) patients had impaired glucose tolerance (IGT) and 272 (68%) were normal. Height, weight, waist circumference, fasting glycemia, high density cholesterol were not different between IGT and non IGT group.
Conclusion: OGTT is necessary in MetS non diabetic situation for detection early prediabetic patients.
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J Reprod Immunol
December 2024
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603 203, India. Electronic address:
Gestational diabetes is marked impaired glucose tolerance, poses various adverse outcomes including increased BMI and obesity. These outcomes results from excess lipid accumulation which is marked by elevated triglycerides. In GDM, placenta exhibits altered lipid metabolism, including reduced fatty acid oxidation and increased triglyceride accumulation.
View Article and Find Full Text PDFBMC Med Inform Decis Mak
January 2025
Department of Obstetrics and Gynecology, Tehran University of Medical Sciences, Tehran, Iran.
Background: Gestational Diabetes Mellitus (GDM) is a common complication during pregnancy. Late diagnosis can have significant implications for both the mother and the fetus. This research aims to create an early prediction model for GDM in the first trimester of pregnancy.
View Article and Find Full Text PDFJ Transl Med
January 2025
Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Background: Obese subjects undergoing weight loss often fear the Yoyo dieting effect, which involves regaining or even surpassing their initial weight. To date, our understanding of such long-term obesity and weight cycling effects is still limited and often based on only short-term murine weight gain and loss studies. This study aimed to investigate the long-term impacts of weight cycling on glycemic control and metabolic health, focusing on adipose tissue, liver, and hypothalamus.
View Article and Find Full Text PDFChin Med
January 2025
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Background: This research aims to explore the anti-obesity potential of Wu-Mei-Wan (WMW), particularly its effects on adipose tissue regulation in obese mice induced by a high-fat diet (HFD). The study focuses on understanding the role of heat shock factor 1 (HSF1) in mediating these effects.
Methods: HFD-induced obese mice were treated with WMW.
Curr Obes Rep
January 2025
Department of Endocrinology and Metabolism, Zhuhai People's Hospital (The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University), Zhuhai, China.
Purpose Of Review: Review the latest data regarding the intersection of adipose tissue (AT) and iron to meet the needs of AT metabolism and the progression of related diseases.
Recent Findings: Iron is involved in fundamental biological metabolic processes and is precisely fine-tuned within the body to maintain cellular, tissue and even systemic iron homeostasis. AT not only serves as an energy storage depot but also represents the largest endocrine organ in the human body, maintaining systemic metabolic homeostasis.
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