In this issue of , Hahn and Lowrey have identified phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) as a novel mechanism for the post-transcriptional induction of fetal hemoglobin (HbF). Furthermore, they demonstrate that this eIF2αP-mediated pathway works synergistically with 2 clinical therapeutics, azacytidine and hydroxyurea (HU), to induce higher levels of HbF than any single agent alone.
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| http://dx.doi.org/10.1182/blood-2013-06-506139 | DOI Listing |
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