Background: Image analyses include computed tomography (CT), magnetic resonance imaging, and xenon ventilation CT, which is new modality to evaluate pulmonary functional imaging.
Objective: To examine the usefulness of dual-energy xenon ventilation CT in asthmatic patients.
Methods: A total of 43 patients 18 years or older who were nonsmokers were included in the study. Xenon CT images in wash-in and wash-out phases were obtained at baseline and after inhalation of methacholine and salbutamol. The degrees of ventilation defects and xenon trappings were evaluated through visual analysis.
Results: Ventilation defects and xenon trapping were significantly increased and decreased after methacholine challenge and salbutamol inhalation, respectively (P < .005). The ventilation abnormalities were not significantly related to the percentage of forced expiratory volume in 1 second (FEV1) or the ratio of FEV1 to forced vital capacity. Xenon trappings after salbutamol inhalation were negatively related to the scores of the asthma control test, wheezing, or night symptoms, with statistical significance (P < .05), whereas, FEV1 showed no significant correlation with symptom scores. Baseline FEV1 was significantly lower and dyspnea and wheezing were more severe in the non-full reversal group than in the full reversal group after salbutamol inhalation in xenon CT (P < .05). The degree of ventilation defects were positively correlated with FEV1 improvement after 3 months of treatment (P = .02).
Conclusion: The results of this study suggest that xenon ventilation CT can be used as a new method to assess ventilation abnormalities in asthma, and these ventilation abnormalities can be used as novel parameters that reflect the status of asthma control and symptom severity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.anai.2013.04.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparability of Quantifying Relative Lung Ventilation with Inhaled Tc-Technegas and Xe in Patients Undergoing Evaluation for Lung Transplantation.
J Nucl Med
January 2025
Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Tc-Technegas was recently approved by the U.S. Food and Drug Administration as a radiopharmaceutical for ventilation scintigraphy.
View Article and Find Full Text PDFXe Image Processing Pipeline: An open-source, graphical user interface application for the analysis of hyperpolarized Xe MRI.
Magn Reson Med
March 2025
Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Purpose: Hyperpolarized Xe MRI presents opportunities to assess regional pulmonary microstructure and function. Ongoing advancements in hardware, sequences, and image processing have helped it become increasingly adopted for both research and clinical use. As the number of applications and users increase, standardization becomes crucial.
View Article and Find Full Text PDFHyperpolarized 129Xe Lung MRI and Spectroscopy in Mechanically Ventilated Mice.
J Vis Exp
October 2024
Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center; Department of Biomedical Engineering, University of Cincinnati; Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center; Department of Pediatrics, University of Cincinnati; Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center;
Article Synopsis
- Hyperpolarized xenon-129 (Xe) is a specialized MRI contrast agent that helps measure various aspects of lung function, making it useful for diagnosing and tracking lung diseases in humans.
- It is approved for clinical use in places like the U.S. and U.K. and offers noninvasive ways to study lung health in preclinical research settings, particularly with mice, which are commonly used in genetic studies.
- The text outlines practical procedures and checklists for effectively using Xe MRI in animal studies, focusing on ensuring accurate data collection related to lung disease monitoring.
Editorial for "Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With Hyperpolarized Xenon MRI".
J Magn Reson Imaging
October 2024
Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With Hyperpolarized Xenon MRI.
J Magn Reson Imaging
October 2024
Center for Pulmonary Imaging Research, Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Article Synopsis
- The study focuses on assessing lung ventilation using hyperpolarized Xe MRI, comparing ventilation defect percentage (VDP) with defect distribution index (DDI) to measure how defects cluster spatially in various pulmonary diseases.
- It involves 421 subjects, including healthy controls and individuals with various obstructive and restrictive lung conditions, analyzed using a 3T MRI system.
- Results indicate that DDI is significantly higher in many pulmonary conditions compared to healthy controls, correlating well with VDP and pulmonary function tests, especially in obstructive disease groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!