AI Article Synopsis
- The study investigated the expression levels of KAI1/CD82 and MRP1/CD9 in laryngeal squamous cell carcinoma (LSCC) and their significance for patient outcomes.
- It analyzed tissue samples from 100 LSCC patients and 30 non-cancerous controls, using techniques like Q-PCR and immunohistochemistry to compare expression levels and relate them to disease characteristics.
- Results indicated that lower expression of these proteins in LSCC correlated with advanced disease features and poor survival, suggesting they could be important biomarkers for assessing LSCC progression and prognosis.
Article Abstract
Objective: The current study explored the expression of KAI1/CD82 and MRP1/CD9 and its significance in laryngeal squamous cell carcinoma (LSCC).
Methods: The expression levels of KAI1/CD82 and MRP1/CD9 in 100 LSCC tissue specimens, as well as in 30 para-LSCC non-carcinomatous tissue specimens randomly taken from the patients, were assessed using the quantitative polymerase chain reaction (Q-PCR) and immunohistochemistry and correlations with pathological parameters of LSCC and their influence on survival function were analyzed.
Results: KAI1/CD82 and MRP1/CD9 showed basically consistent changes in both mRNA and protein expression. Their expression in the 30 LSCC specimens was significantly lower compared with that in the corresponding non-carcinous tissues (P < 0.01 or 0.05), notably correlating with TNM stage, differentiation degree, clinical stage, and lymphatic metastasis (P < 0.01 or 0.05), but not gender, age, and LSCC growth sites (P > 0.05). The median survival of patients with positive KAI1/CD82 and MRP1/CD9 protein expression was longer than that of patients with negative protein expression (P < 0.01 or 0.05). KAI1/CD82 protein expression negatively correlated with MRP1/CD9 protein expression in LSCC (χ(2) = 31.25, P < 0.01).
Conclusion: KAI1/CD82 and MRP1/CD9 may jointly participate in the development of LSCC. They may serve as the markers for judging the infiltration, metastasis, and prognosis of LSCC.
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| http://dx.doi.org/10.7314/apjcp.2013.14.6.3521 | DOI Listing |
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Article Synopsis
- The study investigated the expression levels of KAI1/CD82 and MRP1/CD9 in laryngeal squamous cell carcinoma (LSCC) and their significance for patient outcomes.
- It analyzed tissue samples from 100 LSCC patients and 30 non-cancerous controls, using techniques like Q-PCR and immunohistochemistry to compare expression levels and relate them to disease characteristics.
- Results indicated that lower expression of these proteins in LSCC correlated with advanced disease features and poor survival, suggesting they could be important biomarkers for assessing LSCC progression and prognosis.
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