AI Article Synopsis
- The gene cj0183 in Campylobacter jejuni NCTC 11168 and two human isolates has been found to encode a protein with similarities to TlyC from Brachyspira hyodysenteriae.
- The study aimed to explore how this gene is regulated by examining DNA fragments located upstream of cj0183.
- Results showed that a promoter was present in the upstream region, and mutations in specific areas affected gene transcription levels.
Article Abstract
Gene-nominated cj0183 was identified in Campylobacter jejuni NCTC 11168 and in two human isolates 81116 and 81-176. It encodes a protein which shows partial homology to TlyC of Brachyspira hyodysenteriae. The aim of this work was to determine the mechanisms of gene regulation by cloning DNA fragments lying upstream of the cj0183 gene. The β-galactosidase activity determined for the strain harboring the plasmid with the fragment upstream of cj0183 indicated the presence of a promoter in this DNA region. Mutations in cj0183 -10 region, -16 region, and -35 region resulted in changes in gene transcription.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824568 | PMC |
| http://dx.doi.org/10.1007/s00284-013-0420-8 | DOI Listing |
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