Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides.

Chem Commun (Camb)

Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Tokyo 113-8656, Japan.

Published: September 2013

Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.

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Source
http://dx.doi.org/10.1039/c3cc44434aDOI Listing

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