AI Article Synopsis
- The study investigates the significance of lymphatic vessel invasion (LVI) in esophageal squamous cell carcinoma (ESCC) using the D2-40 monoclonal antibody.
- Findings reveal that patients with LVI have a higher rate of lymph node metastasis (70%) compared to those without LVI (21%), and their median survival time is shorter (26 months vs. 43 months).
- However, while LVI indicates nodal metastasis, it isn't an independent predictor of overall survival, with other factors like lymphatic node metastasis and clinical stage being more significant.
Article Abstract
Objective: This study aims to investigate the clinicopathologic significance of lymphatic vessel invasion (LVI) labeled by D2-40 monoclonal antibody in esophageal squamous cell carcinoma (ESCC).
Methods: Immunohistochemical assay was used to detect the expression of D2-40 and LVI in 107 ESCC patients. Then, the correlation between the clinicopathologic feature and the overall survival time of the patients was analyzed.
Results: The lymph node metastasis rates were 70% and 21% in the LVI-positive and LVI-negative groups, respectively. The nodal metastasis rate was higher in the LVI-positive group than in the LVI-negative group. Multivariate regression analysis showed that LVI was related to nodal metastasis (P<0.001). The median survival time of the patients was 26 and 43 months in the LVI-positive and LVI-negative groups, respectively. Although univariate regression analysis showed significant difference between the two groups (P=0.014), multivariate regression analysis revealed that LVI was not an independent prognostic factor for overall survival in the ESCC patients (P=0.062). Lymphatic node metastasis (P=0.031), clinical stage (P=0.019), and residual tumor (P=0.026) were the independent prognostic factors.
Conclusion: LVI labeled by D2-40 monoclonal antibody is a risk factor predictive of lymph node metastasis in ESCC patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719196 | PMC |
| http://dx.doi.org/10.7497/j.issn.2095-3941.2013.02.003 | DOI Listing |
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