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Efficacy of desvenlafaxine 50 mg compared with placebo in patients with moderate or severe major depressive disorder: a pooled analysis of six randomized, double-blind, placebo-controlled studies. | LitMetric
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Efficacy of desvenlafaxine 50 mg compared with placebo in patients with moderate or severe major depressive disorder: a pooled analysis of six randomized, double-blind, placebo-controlled studies.

George I Papakostas Larry Culpepper Rana S Fayyad Jeff Musgnung Christine J Guico-Pabia

Int Clin Psychopharmacol

aMassachusetts General Hospital, Harvard Medical School bDepartment of Family Medicine, Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts cPfizer Inc., Collegeville, Pennsylvania, USA.

Published: November 2013

This study assessed the efficacy of desvenlafaxine 50 mg/day compared with placebo for treating moderate or severe major depressive disorder (MDD). Data were pooled from six double-blind, placebo-controlled, desvenlafaxine 50 mg/day fixed-dose studies in adults with MDD. The primary endpoint was improvement in 17-item Hamilton Rating Scale for Depression (HAM-D17) scores from baseline at week 8. HAM-D17 changes were evaluated in patients with moderate (18

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http://dx.doi.org/10.1097/YIC.0b013e3283638fbdDOI Listing

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