Objective: To investigate the relation between handling characteristics and application time of four composite materials with subjectively different viscosities.
Methods: Eight experienced faculty members placed one Class II and one Class IV restoration in a random sequence into pre-prepared plastic teeth mounted on a typodont model, each using 4 types of composites (Herculite Précis (M1), Kerr; Tertic N-Ceram (M2), Ivoclar Vivadent; Filtek Z350 (M3), 3M-ESPE; Charisma Opal (M4), HareausKulzer), resulting in a total of 64 restorations. The application process was filmed with a high definition video camera. Two evaluators watched the recordings in a random sequence as well, timed the composite application and wrote down their observations, which were dichotimised into positive and negative ones. Application times were analysed with a two-way Kruskal Wallis test (time x dentist) and the observation data were analysed with a chi-square test (P < 0.05).
Results: Materials did not differ in their application time (P > 0.05). The mean application time was 12 ¼ minutes for the Class II and 9 ¾ minutes for Class IV restorations. However, there were statistically significant differences between the dentists in terms of application time. The observation data showed no significant difference between Class II and Class IV restorations but there were significant material differences (P < 0.05). M2 yielded 6% negative observations, while the other materials were between 35% and 38%.
Conclusion: There was no association between the handling characteristics of the tested composite resins and the speed of application. However, one of the tested materials (M2) showed significantly less problems in the application process.
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J Orthop Surg Res
January 2025
Guizhou Medical University, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, People's Republic of China.
Background: Wound repair methods are commonly used in clinical practice, such as skin graft and flap repair, which can cause secondary injuries, and high costs. Many methods for skin stretching and repair have been reported domestically and internationally. However, their clinical use is limited owing to lack of equipment, complexity, and high costs.
View Article and Find Full Text PDFGenome Med
January 2025
Hereditary Cancer Group, Oncobell Program, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Av. Gran Via 199-203, L'Hospitalet del Llobregat, 08908, Spain.
Background: Germline heterozygous pathogenic variants (PVs) in TP53 cause Li-Fraumeni syndrome (LFS), a condition associated with increased risk of multiple tumor types. As the associated cancer risks were refined over time, clinical criteria also evolved to optimize diagnostic yield. The implementation of multi-gene panel germline testing in different clinical settings has led to the identification of TP53 PV carriers outside the classic LFS-associated cancer phenotypes, leading to a broader cancer phenotypic redefinition and to the renaming of the condition as "heritable TP53-related cancer syndrome" (hTP53rc).
View Article and Find Full Text PDFEur Spine J
January 2025
Department of Spinal Surgery, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang, 050051, Hebei, P.R. China.
Objective: This study aimed to compare the use of the endoscopic drill (ED) with the extra-endoscopic trephine (EET) in treating lumbar disc herniations with regard to efficiency, safety, and clinical outcomes.
Methods: From January 2022 and June 2023, 136 patients who had the single-level LDH and received the transforaminal endoscopic surgery were divided into two groups according to the foraminoplasty technique: the EET group (n = 69) and the ED group (n = 67). Surgery-related parameters, complications, Visual Analogue Scale (VAS, 0-10), and Oswestry Disability Index (ODI, 0-100%) were assessed and compared among two groups.
Nat Med
January 2025
Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting PrP in the brain is an established strategy to prevent or stall templated misfolding of PrP. Here we developed in vivo cytosine and adenine base strategies delivered by adeno-associated viruses to permanently modify the PRNP locus to achieve PrP knockdown in the mouse brain.
View Article and Find Full Text PDFJ Expo Sci Environ Epidemiol
January 2025
Environmental Research Group, School of Public Health, Imperial College London, London, UK.
Background: Accurate estimates of personal exposure to ambient air pollution are difficult to obtain and epidemiological studies generally rely on residence-based estimates, averaged spatially and temporally, derived from monitoring networks or models. Few epidemiological studies have compared the associated health effects of personal exposure and residence-based estimates.
Objective: To evaluate the association between exposure to air pollution and cognitive function using exposure estimates taking mobility and location into account.
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