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Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans. | LitMetric
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Cytotoxic and anti-tumor activities of lignans from the seeds of Vietnamese nutmeg Myristica fragrans.

Phuong Thien Thuong Tran Manh Hung Nguyen Minh Khoi Hoang Thi My Nhung Nguyen Thi Chinh Nguyen Thi Quy Tae Su Jang Minkyun Na

Arch Pharm Res

Vietnam National Institute of Medicinal Materials, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam.

Published: March 2014

Four lignans, meso-dihydroguaiaretic acid (DHGA), macelignan, fragransin A2 and nectandrin B, were isolated from the seeds of Myristica fragrans (Vietnamese nutmeg) and investigated for their cytotoxic activity against eight cancer cell lines. Of these, DHGA exhibited potent cytotoxicity against H358 with IC50 value of 10.1 μM. In addition, DHGA showed antitumor activity in allogeneic tumor-bearing mice model.

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http://dx.doi.org/10.1007/s12272-013-0185-4DOI Listing

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