Streptococcus suis (S. suis) is a major pathogen in the pig industry and an important zoonotic agent that causes severe invasive diseases in humans. Previous studies based on multilocus sequence typing (MLST) and the associations between sequence types and genotypes or virulence suggested that North American S. suis serotype 2 isolates are composed of multiple populations. This study investigated the population structure of S. suis serotype 2 isolates in China. We constructed a phylogenetic tree for S. suis serotype 2 isolates based on 16S rRNA gene typing and MLST, studied associations between clades and sources, analyzed the genotype distributions of virulence markers [muramidase-released protein (MRP), extracellular protein factor (EF), and suilysin (SLY)] in different clades, computed the selection pressures for these virulence marker genes, and verified the associations between clades and virulence. There were two primary clades (populations) in the phylogenetic tree of S. suis serotype 2. The two populations were associated with different tissue tropisms. The genotypic distributions and selection pressures of MRP, EF, and SLY were different between the two populations, which suggested that they had different evolutionary paths. The two populations also displayed differences in virulence in experimentally infected mice. The results provide insights into the population structure of S. suis serotype 2 isolates in China and suggest that S. suis serotype 2 clade 1 is an overlooked population that deserves further evaluation.
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Article Synopsis
- Streptococcus suis serotype 2 (SS2) is a zoonotic bacteria that can cause serious diseases, but how it avoids the body's immune system is not well understood.
- A study identified a specific protein mutation in SS2 that leads to increased neutrophil responses, yet the mutated bacteria survive poorly in the bloodstream compared to the original strain.
- The deletion of this protein results in a weaker protective capsule and boosts the bacteria's ability to form biofilms; however, it also decreases the bacteria's survival within immune cells, highlighting potential targets for preventing infections.
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