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In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the review entitled "Metabolic tug-o-war: Microbial metabolism shapes colonization resistance against enteric pathogens" share their perspectives on the field and their lives as scientists.
View Article and Find Full Text PDFIs a syndromic approach well suited to foodborne disease surveillance? Implication for salmonellosis surveillance and prevention in France from a "One Health" perspective.
Prev Vet Med
January 2025
University of Lyon - French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Laboratory of Lyon, Epidemiology and support to Surveillance Unit, Lyon, France. Electronic address:
In response to the increasing emergence of zoonotic pathogens, flexible, multisectoral surveillance systems capable of generating alerts thanks to rapid, nonspecific detection, are crucial before pathogens reach human populations. Syndromic surveillance has proven to be a breakthrough for near real-time disease surveillance in the public health sector. It relies on existing nonspecific data, usually collected for other purposes.
View Article and Find Full Text PDFRat Models of Breast Cancer.
Adv Exp Med Biol
January 2025
Lester & Sue Smith Breast Center, Baylor College of Medicine, Houston, TX, USA.
As the first mammal to be domesticated for research purposes, rats served as the primary animal model for various branches of biomedical research, including breast cancer studies, up until the late 1990s and early 2000s. During this time, genetic engineering of mice, but not rats, became routine, and mice gradually supplanted rats as the preferred rodent model. But recent advances in creating genetically engineered rat models, especially with the assistance of CRISPR/Cas9 technology, have rekindled the significance of rats as a critical model in exploring various facets of breast cancer research.
View Article and Find Full Text PDFCost Effectiveness of Fixation Versus Total Hip Arthroplasty in Vancouver B2 Periprosthetic Femur Fractures: A Predictive Markov Analysis.
J Am Acad Orthop Surg
January 2025
From the Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA (Scott, Blackburn, Prasad, Lim, Lavoie-Gagne, Melnic, and Bedair), and the Department of Orthopaedic Surgery, Newton-Wellesley Hospital, Newton, MA (Scott, Blackburn, Prasad, Lim, Melnic, and Bedair).
Background: Although Vancouver B2 periprosthetic fractures (PPFs) have been historically managed with revision total hip arthroplasty (rTHA), open reduction and internal fixation (ORIF) has been proposed as an alternative option for reasons including lower cost and surgical time. The purpose of this study was to, therefore, create a Markov model to assess the cost effectiveness of ORIF versus rTHA for Vancouver B2 periprosthetic femur fractures and evaluate various inflection points for varying costs and outcome measures.
Methods: A Markov model was built using discrete and mutually exclusive health states of the hypothetical patient with Vancouver B2 PPF.
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