AI Article Synopsis
- The study explored how age and APOE genotype affect cognitive decline in elderly individuals not diagnosed with dementia during a simulated Alzheimer's disease prevention trial.
- Cognitive testing over four years showed a more significant decline in those with the APOE ε4+ genotype, a known risk factor for Alzheimer's, compared to APOE ε4- participants, especially as age increased.
- Findings suggest that considering APOE genotype and age is crucial when designing Alzheimer's prevention trials, as older individuals with the ε4+ allele may exhibit earlier signs of cognitive decline.
Article Abstract
Objective: This study examined the impact of age and apolipoprotein E (APOE) genotype on the rate of cognitive decline in nondemented elderly participants in a simulated Alzheimer's disease (AD) primary prevention treatment trial carried out by the Alzheimer's Disease Cooperative Study.
Method: Cognitive tests were administered at baseline and at four subsequent annual evaluations to 417 nondemented participants (172 men, 245 women) between the ages of 74 and 93 (M = 79.13 ± 3.34). APOE genotyping was available for 286 of the participants.
Results: Four-year decline was evident on measures of orientation, memory, executive function, and language. Faster decline was evident in APOE ε4+ (a genetic risk factor for AD; n = 73) than in ε4- participants (n = 213), even after controlling for education, gender, ethnicity, and baseline functional and cognitive abilities. This discrepancy increased with age, indicating an Age × Genotype interaction.
Conclusion: These results are consistent with population-based studies, and extend the findings to a carefully screened sample that meets inclusion and exclusion criteria for an AD primary prevention trial. The interaction between age and APOE genotype on rate of decline suggests that preclinical disease may be overrepresented in older ε4+ individuals. Thus, APOE genotype and age should be considered in the design of AD primary prevention treatment trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3831285 | PMC |
| http://dx.doi.org/10.1037/a0032707 | DOI Listing |
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