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Age-associated remodeling of the intestinal epithelial barrier. | LitMetric

Age-associated remodeling of the intestinal epithelial barrier.

J Gerontol A Biol Sci Med Sci

Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK73104, USA.

Published: September 2013

AI Article Synopsis

Article Abstract

Disorders of the gastrointestinal tract are common in the elderly people; however, the precise trait(s) of aging that contribute to the vulnerability of the gastrointestinal tract are poorly understood. Recent evidence suggests that patients with gastrointestinal disorders have increased intestinal permeability. Here, we address the hypothesis that disruption of the intestinal barrier is associated with aging. Our results demonstrated that permeability was significantly higher in colonic biopsies collected from old baboons compared with young baboons. Additionally, colonic tissue from the older animals had decreased zonula occluden-1, occludin, and junctional adhesion molecule-A tight junction protein expression and increased claudin-2 expression. Upregulation of miR-29a and inflammatory cytokines IFN-γ, IL-6, and IL-1β was also found in colonic biopsies from old baboons relative to young baboons. These results show for the first time that a pivotal contributing factor to geriatric vulnerability to gastrointestinal dysfunction may be increased colonic permeability via age-associated remodeling of intestinal epithelial tight junction proteins.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3738030PMC
http://dx.doi.org/10.1093/gerona/glt106DOI Listing

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