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Radiate & Educate: Empowering Future Physicians through an International Radiation Oncology Student Newsletter.
Appl Radiat Oncol
July 2024
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center.
Background: The field of radiation oncology (RO) is frequently overlooked by medical students due to limited exposure during traditional medical school curricula. Initiatives aimed at increasing exposure while creating opportunities for medical student engagement are vital. Here, we present the inception, 1.
View Article and Find Full Text PDFImpact of particulate matter exposure on melanoma risk: A multicentre case-control study.
J Eur Acad Dermatol Venereol
January 2025
Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
Background: The relationship between particulate matter (PM) exposure and melanoma risk remains largely unexplored. This study aims to investigate the association between PM10 and PM2.5 long-term exposure and melanoma risk.
View Article and Find Full Text PDFIt's all downstream from here: RTK/Raf/MEK/ERK pathway resistance mechanisms in glioblastoma.
J Neurooncol
January 2025
MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada.
Background: The receptor tyrosine kinase (RTK)/Ras/Raf/MEK/ERK signaling pathway is one of the most tumorigenic pathways in cancer, with its hyperactivation strongly linked to the aggressive nature of glioblastoma (GBM). Although extensive research has focused on developing therapeutics targeting this pathway, clinical success remains elusive due to the emergence of resistance mechanisms.
Objective: This review investigates how inhibition of the RTK/Ras/Raf/MEK/ERK pathway alters transcription factors, contributing to acquired resistance mechanisms in GBM.
Digital redesign of the radiotherapy course for medical students with a blended learning approach.
Strahlenther Onkol
January 2025
Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Purpose: Due to the need for high-quality teaching, we present a new blended learning concept combining digital modules, interactive seminars, and clinical experience. Furthermore, we evaluated its acceptance among students.
Methods: A new concept for teaching was applied to the radiotherapy module and made available via the Hannover Medical School (MHH) learning management system as part of a blended learning concept with educational films, multimedia learning modules, online seminars, and onsite practical training.
Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom.
Sci Rep
January 2025
Radiation Biophysics and Radiobiology Laboratory, Physics Department, University of Pavia, Pavia, Italy.
We present new developments for an ab-initio model of the neutron relative biological effectiveness (RBE) in inducing specific classes of DNA damage. RBE is evaluated as a function of the incident neutron energy and of the depth inside a human-sized reference spherical phantom. The adopted mechanistic approach traces neutron RBE back to its origin, i.
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