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MGATAF: multi-channel graph attention network with adaptive fusion for cancer-drug response prediction.
BMC Bioinformatics
January 2025
School of Computing and Artificial Intelligence, Southwest Jiaotong University, Chengdu, 611756, Sichuan, China.
Background: Drug response prediction is critical in precision medicine to determine the most effective and safe treatments for individual patients. Traditional prediction methods relying on demographic and genetic data often fall short in accuracy and robustness. Recent graph-based models, while promising, frequently neglect the critical role of atomic interactions and fail to integrate drug fingerprints with SMILES for comprehensive molecular graph construction.
View Article and Find Full Text PDFA Phase II Trial of Onapristone and Fulvestrant for Patients With ER+ and HER2- Metastatic Breast Cancer.
Clin Breast Cancer
December 2024
Medical Oncology and Palliative Care, Department of Medicine, Breast Cancer Disease Oriented Team, University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792-3252.
Background: The SMILE study is a multi-institutional phase II clinical trial to determine the efficacy and safety of an antiprogestin, onapristone, in combination with fulvestrant as second-line therapy for patients with ER+, PgR+/-, HER2- metastatic breast cancer. This study was terminated early and herein, we report patient characteristics, and outcomes.
Methods: Eligibility criteria included disease progression on ≥2 lines of prior therapy, ECOG performance status ≤ 2, measurable disease per RECIST 1.
Bone marrow mesenchymal stem cells ameliorate diet-induced obesity by activating thermogenesis and alleviating inflammation in adipose tissue.
Biochem Biophys Res Commun
February 2025
Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, PR China. Electronic address:
Obesity and its related metabolic disorders seriously threaten our health and significantly reduce our life expectancy. The aim of the present study was to explore the effects of bone marrow mesenchymal stem cells (BMSCs) on high-fat diet (HFD)-induced obesity mice. The results demonstrated that BMSCs significantly reduced body weight, improved glucose tolerance and insulin sensitivity in obese mice.
View Article and Find Full Text PDFAlcohol and emotion: Analyzing convergence between facially expressed and self-reported indices of emotion under alcohol intoxication.
Psychol Addict Behav
January 2025
Department of Psychology, University of Illinois, Urbana-Champaign.
Objective: Emotion measurement is central to capturing acute alcohol reinforcement and so to informing models of alcohol use disorder etiology. Yet our understanding of how alcohol impacts emotion as assessed across diverse response modalities remains incomplete. The present study leverages a social alcohol-administration paradigm to assess drinking-related emotions, aiming to elucidate impacts of intoxication on self-reported versus behaviorally expressed emotion.
View Article and Find Full Text PDFDesign, Development, and Evaluation of a 3D-Printed Buccal Myomucosal Flap Simulator.
Cleft Palate Craniofac J
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Objective: Buccal myomucosal flap procedures have become a critical tool in the armamentarium of the cleft surgeon. Mastering this technique is complex and providing sufficient training opportunities presents significant challenges. Our study details the design, development, and evaluation of a low-cost, high-fidelity buccal myomucosal flap surgical simulator.
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