AI Article Synopsis
- Sensory cells and neuronal dendrites are influenced by adhesive interactions, similar to what is found in epithelial cells.
- These interactions involve specific proteins and complexes, such as the Crumbs complex and various cadherins, that help shape the structure and function of these cells.
- The review proposes that understanding how epithelial cells form can offer insights into the development and morphology of dendrites in neurons.
Article Abstract
The ciliated receptive endings of sensory cells and the dendrites of other neurons are shaped by adhesive interactions, many of which depend on machinery also present in epithelia. Sensory cells are shaped by interactions with support cells through adhesion junctions via the Crumbs complex, tight junction components such as claudins, as well as interactions with apical extracellular matrix composed of zona pellucida domain proteins. Neuronal dendrites are shaped by adhesion machinery that includes cadherins, catenins, afadin, L1CAM, CHL1, Sidekicks, Contactin and Caspr, many of which are shared with epithelia. This review highlights this shared machinery, and suggests that mechanisms of epithelial morphogenesis may thus provide a guide to understanding dendrite morphogenesis.
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| http://dx.doi.org/10.1016/j.conb.2013.06.011 | DOI Listing |
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