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Biomarkers.
Alzheimers Dement
December 2024
Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Background: Parkinson's (PD) is common and debilitating with over half of patients progressing to postural instability, dementia or death within 10 years. However, onset and rate of progression is highly variable, reflecting heterogeneity in underlying pathology, and biomarker studies to-date have been limited to a single modality or assessed patients with established cognitive impairment.
Method: We assessed multimodal neuroimaging and plasma biomarkers in 98 PD patients (mean disease duration at baseline 4.
Background: Interest and consumption of plant-based diets (PBD) in the 21 century continued to increase, particularly in western societies, with the perception that PBDs are associated with beneficial health outcomes and a reduced environmental footprint. Evidence suggests that PBDs may be protective against neurodegenerative diseases, such as Alzheimer's disease (AD). Health effects of PBDs such as reduction of inflammation, shift in gut microbiota composition, reduced risk of type 2 diabetes and cardiovascular disease are all believed to attribute to reduced AD risk.
View Article and Find Full Text PDFBackground: To investigate the relationships among plasma biomarkers, basal forebrain, and spatial navigation.
Method: A total of 78 participants were enrolled, including 23 normal controls (NC), 38 subjective cognitive decline (SCD), and 17 mild cognitive impairment (MCI) patients. According to the spatial navigation distance errors in the human version of the Morris Water Maze, the whole cohort was divided into the good spatial navigation performance (gSN) group and the bad spatial navigation performance (bSN) group, with 39 cases in each group.
Biomarkers.
Alzheimers Dement
December 2024
Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Background: Arterial spin labelling (ASL) is a non-invasive MRI technique for quantifying cerebral blood flow (CBF), used for monitoring changes over the course of a disease or treatment. A crucial parameter in ASL is the post-labelling delay (PLD), determined by the time it takes for blood to travel from the labeling location to the tissue under investigation. Time-encoded ASL (te-ASL) utilizes multiple PLDs for more accurate quantification.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Institute for Neurodegenerative Diseases (IND) Florida, Boca Raton, FL, USA.
Background: Alzheimer's disease (AD), Dementia with Lewy Bodies (DLB), and other neurodegenerative diseases (NDD) develop over an extended preclinical period, sharing common risk factors and underlying pathophysiological mechanisms. Plasma proteins, including Amyloid-beta peptides (Aβ) and Tau isoforms, facilitate differential diagnosis of NDD in their earliest stages, allowing for timely delivery of targeted interventions. Blood-based biomarkers may also serve as a reliable means of monitoring disease progression and evaluating the effectiveness of individualized interventions across the spectrum of disease.
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