Infections caused by bacterial biofilms are a significant global health problem, causing considerable patient morbidity and mortality and contributing to the economic burden of infectious disease. This review describes diverse strategies to combat bacterial biofilms, focusing firstly on small molecule interference with bacterial communication and signaling pathways, including quorum sensing and two-component signal transduction systems. Secondly we discuss enzymatic approaches to the degradation of extracellular matrix components to effect biofilm dispersal. Both of these approaches are based upon non-microbicidal mechanisms of action, and thereby do not place a direct evolutionary pressure on the bacteria to develop resistance. Such approaches have the potential to, in combination with conventional antibiotics, play an important role in the eradication of biofilm based bacterial infections.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795836 | PMC |
| http://dx.doi.org/10.1016/j.coph.2013.07.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
(P)ppGpp synthetase Rel facilitates cellulose formation of biofilm by regulating glycosyltransferase in Brucella abortus.
Int J Biol Macromol
January 2025
College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University; Yangling, Shaanxi 712100, China. Electronic address:
Biofilms are complex adhesive structures that establish chronic infection and allow robust protection from external stressors such as antibiotics. Cellulose as one of the compositions of bacteria biofilm which protect bacteria from stress, host immune responses and resistance to antibiotics. Bacterial stress responses are regulated via guanosine pentaphosphate and tetraphosphate (p)ppGpp.
View Article and Find Full Text PDFBiological studies reveal the role of trpA gene in biofilm formation, motility, hemolysis and virulence in Vibrio anguillarum.
Microb Pathog
January 2025
Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China; Marine Biomedical Science and Technology Innovation Platform of Lin-gang Special Area, Shanghai 201306, China. Electronic address:
Vibrio anguillarum is a pathogen responsible for vibriosis in aquaculture animals. The formation of bacterial biofilm contributes to infections and increases resistance to antibiotics. Tryptophanase and its substrate tryptophan have been recognized as signal molecules regulating bacterial biofilm formation.
View Article and Find Full Text PDFAntibiotic-based micelles with bone-targeting and pH-responsive properties for infectious osteomyelitis treatment.
J Colloid Interface Sci
January 2025
College of Chemistry and Environment, Southwest Minzu University, Chengdu 610041 China. Electronic address:
We developed antibiotic-based micelles with bone-targeting and charge-switchable properties (P-CASMs) for treating infectious osteomyelitis. The amphiphilic molecules are formed by combining ciprofloxacin (CIP) with ligand 1 through a mild salifying reaction, and spontaneously self-assemble into antibiotic-based micelles (ASMs) in aqueous solution. Acrylate groups on ligand 1 enable cross-linking of ASMs with pentaerythritol tetra(mercaptopropionate) via a click reaction, forming pH-sensitive cross-linked micelles (CASMs).
View Article and Find Full Text PDFBoron-dependent autoinducer-2-mediated quorum sensing stimulates the Cr(VI) reduction of Leucobacter chromiireducens CD49.
J Environ Manage
January 2025
Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address:
Traditionally, abiotic factors such as pH, temperature, and initial Cr(VI) concentration have been undoubtedly recognized as the external driving forces that dramatically affect the microbial-mediated remediation of Cr(VI) pollutants. However, concentrating on whether and how the biological behaviors and metabolic activities drive the microbial-mediated Cr(VI) detoxification is a study-worthy but little-known issue. In this study, Leucobacter chromiireducens CD49 isolated from heavy-metal-contaminated soil was identified to tolerate 8000.
View Article and Find Full Text PDFAntibacterial activity and multi-target mechanism of harmane against Escherichia coli O157:H7 and its application on ready-to-eat leafy greens.
Int J Food Microbiol
January 2025
School of Life Science and Technology, Shandong Second Medical University, Weifang, Shandong, China. Electronic address:
Escherichia coli O157:H7 has caused many foodborne disease outbreaks and resulted in unimaginable economic losses. With the evolution of food consumption, people prefer natural preservatives. In this study, the natural agent harmane exhibited potential activity against E.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!