Objective: To study the relationship of the expressions of p53 and mdm2 in leukoplakia cancer.
Methods: RT-PCR was used to detect the mRNA of p53, mdm2 in patients with leukoplakia cancer. The frequencies of p53, mdm2 in peripheral blood were detected by flow cytometric analysis.
Results: The expression of p53mRNA in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were 7.7%, 27.3%,33.3%, 56.8%, respectively. The frequencies of p53 in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were (0.3±0.1)%, (1.6±0.9)%, (1.9±1.1)%, (3.4±1.8)%. The expression of mdm2 mRNA in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were 0.0%, 6.8%, 11.1%, 37.8%, respectively. The frequencies of mdm2 in normal oral mucosa, simple oral leukoplakia, no-simple oral leukoplakia and leukoplakia cancer were (0.1±0.1)%, (0.8±0.6)%, (1.2±0.8)%, (1.2±0.8)%. There was a positively correlation between p53 mRNA and mdm2 mRNA.
Conclusions: The positive rate of p53 and mdm2 cells in the peripheral blood increases in patients with leukoplakia cancer tissue and has positive correlation with the severity of leukoplakia cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1995-7645(13)60147-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A non-local dual-stream fusion network for laryngoscope recognition.
Am J Otolaryngol
December 2024
Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin 300192, China; Institute of Otolaryngology of Tianjin, Tianjin, China; Key Laboratory of Auditory Speech and Balance Medicine, Tianjin, China; Key Clinical Discipline of Tianjin (Otolaryngology), Tianjin, China; Otolaryngology Clinical Quality Control Centre, Tianjin, China.
Purpose: To use deep learning technology to design and implement a model that can automatically classify laryngoscope images and assist doctors in diagnosing laryngeal diseases.
Materials And Methods: The experiment was based on 3057 images (normal, glottic cancer, granuloma, Reinke's Edema, vocal cord cyst, leukoplakia, nodules and polyps) from the dataset Laryngoscope8. A classification model based on deep neural networks was developed and tested.
Demographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study.
BMC Oral Health
December 2024
Dental Sciences Graduate Program. Federal University of Espirito Santo (UFES), Avenida Maruípe 1468, Maruípe, Vitória, 29040-090, ES, Brazil.
Background: Clinicopathological diagnosis and follow-up of oral lichen planus and leukoplakia are necessary due to its potential for malignant transformation and the need to differentiate it from other lichenoid diseases and proliferative verrucous leukoplakia. This study aimed to classify and compare sociodemographic and clinicopathological features among patients with oral lichen planus, oral lichenoid lesions and proliferative verrucous leukoplakia.
Methods: A transversal observational study in which oral leukoplakia and oral lichen planus patients were surveyed at the Oral Pathological Anatomy Service and Applied Biotechnology Laboratory was conducted.
Authors' Reply: "Surgical Treatment Compared With 'Wait and See' in Patients Affected by Oral Leukoplakia to Prevent Oral Cancer: Preliminary Data From a Multicenter Randomized Controlled Trial".
Oral Dis
December 2024
Dipartimento di Scienze Biomediche Chirurgiche e Odontoiatriche, Università Degli Studi di Milano, Milan, Italy.
Considering SOD and miRNA analysis as potential prognostic markers in white lesion malignant transformation: A report of two cases.
Medicine (Baltimore)
December 2024
Department of Medical Biology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Košice, Slovak Republic.
Article Synopsis
- Predictive biomarkers can help identify oral leukoplakia with a higher risk of becoming cancerous, which is crucial for timely intervention.
- Two patients presented with oral burning sensations and white lesions, leading to a diagnosis confirmed through tissue analysis.
- The study found specific changes in microRNA expressions and antioxidant enzyme activities in patients, indicating a link between these molecular changes and the risk of malignant transformation.
Case report: Non-invasive cyto-salivary sampling and biomarker detection via ELISA versus histopathology for diagnosing oral potentially malignant disorders - Insights from a case-control study.
Front Immunol
December 2024
Department of Experimental Medicine (DIMES), University of Genoa, Genoa, Italy.
Oral leukoplakia is classified among oral potentially malignant disorders (OPMDs) by the World Health Organization (WHO). The visual oral examination (VOE) is the most used method for identifying lesions in their early stages. Given that the diagnosis of oral cancer is often late, there is an urgent need for early detection and examination of oral lesions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!