The advancement of a series of ligand efficient 2-amino-[1,2,4]triazolo[1,5-a]pyridines, initially identified from high-throughput screening, to a JAK2 inhibitor with pharmacodynamic activity in a mouse xenograft model is disclosed.
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| http://dx.doi.org/10.1016/j.bmcl.2013.06.008 | DOI Listing |
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