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Aza-Michael access to fluoroalkylidene analogues of biomolecules. | LitMetric
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Aza-Michael access to fluoroalkylidene analogues of biomolecules.

Anaïs Prunier Charlène Calata Julien Legros Jacques Maddaluno Emmanuel Pfund Thierry Lequeux

J Org Chem

Laboratoire de Chimie Moléculaire et Thioorganique, CNRS UMR 6507 & FR3038, Normandie Université, UNICAEN, ENSICAEN, 6 Boulevard du Maréchal Juin, 14050 Caen Cedex, France.

Published: August 2013

The synthesis of fluoroaminosulfones derived from piperidine and nucleic bases followed by the study of their chemical behavior in the modified Julia reaction are described. The resulting aminosulfones open a straightforward access to a series of new fluorinated biomolecules including a potent DPP-II inhibitor and acyclonucleoside analogues as potential enzyme inhibitors.

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 Source
http://dx.doi.org/10.1021/jo401356jDOI Listing

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