Tumor cell motility and invasion rely on actin cytoskeleton rearrangements mediated by the activation of RhoGTPase signaling pathways. Invadopodia are membrane-degrading protrusions that mediate extracellular matrix degradation. Here, we provide procedures for imaging RhoGTPase biosensors in tumor cells during the formation of invadopodia and matrix degradation.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784404 | PMC |
| http://dx.doi.org/10.1007/978-1-62703-538-5_22 | DOI Listing |
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