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http://dx.doi.org/10.1002/anie.201302822 | DOI Listing |
ACS Nano
January 2025
School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Intracellular bacteria can evade the attack of the immune system and the bactericidal effects of most antibiotics due to the protective effect of the host cells. Herein, inspired by the stimuli-responsive behaviors of biological ion channels, a kind of synergistic cascade potassium ion (K)-responsive nanoparticles gated with K-responsive polymers is ingeniously designed to target intracellular bacteria and then control drug release. Due to the cooperative interaction of host-guest complexation and conformational transition of K-responsive polymers, the grafted gates based on these polymers could recognize high K concentration to reverse the negatively charged nanoparticles into positively charged ones for targeting bacteria and subsequently inducing a switch from the hydrophobic shrinking "off" state to the hydrophilic stretching "on" state for drug release.
View Article and Find Full Text PDFChembiochem
December 2024
Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin, 300071, P. R. China.
Smart shape-memory DNA hydrogels, which can respond to various types of external stimuli and undergo macroscopic shape deformations, have shown great potential in various applications. By constructing free-standing films, the deformation and response properties of these hydrogels can be further enhanced, and visualized deformation can be achieved. However, DNA hydrogels that can exhibit rapid and high-degree shape deformations, such as the inverse shape deformations, are still lacking.
View Article and Find Full Text PDFACS Nano
December 2024
Technical University of Munich, TUM School of Natural Sciences, Department of Physics, Chair for Functional Materials, James-Franck-Str. 1, 85748 Garching, Germany.
Organic conducting polymer poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) has garnered enormous attention in organic electronics due to its low-cost solution processability, highly tunable conductivity, superior mechanical flexibility, and good biocompatibility together with excellent atmospheric stability. Nevertheless, limited electrical properties and unfavorable water instability of pristine PEDOT:PSS film impede its further implementation in a broad spectrum of practical applications. In this work, the successful tailoring of the intrinsic electrostatic interaction within PEDOT:PSS and consequent optimized electrical properties are enabled by a simple yet effective ionic salt post-treatment strategy.
View Article and Find Full Text PDFLangmuir
December 2024
Department for Molecules and Materials, MESA+ Institute and Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Employing particles as a label is a common approach for signal amplification in various surface-based biosensors. However, the size dependency of adhesive forces can increase the likelihood of nonspecific interactions between the particles and surface. Hence, using microscale particles in surface-based sensors requires both developing surface chemistries with enhanced antifouling properties and precise methods for evaluating these properties.
View Article and Find Full Text PDFChemistry
November 2024
Smart Hybrid Materials (SHMs) Laboratory, Division of Physical Science and Engineering, King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia.
The mechanical actuation of smart materials has garnered considerable attention in biological and medical research due to their ability to mimic biological processes at both molecular level, such as conformational changes in individual compounds, and at the macroscopic level, where polymeric substrates respond to external stimuli. In this study, we present a polymeric composite incorporating a novel urea macrocycle as a filler, forming a soft actuator that responds to various organic solvent vapors. The underlying actuation mechanism is attributed to crystalline phase transition of urea macrocycle, driven by the host-guest interactions with diverse guest molecules.
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