Objective: To estimate the prevalence of dyspepsia in the general population aged over 20 in western Iran.
Methods: The cross-sectional study was conducted among the randomly selected general population over the age of 20 years in Sanandaj city. Iran, from April to December 2009. A questionnaire containing demographic, symptoms and history variables was used. Dependent variables were self-reported gastrointestinal symptoms. The prevalence of dyspepsia in different groups was analysed using chi square test, while logistic regression analysis was done to determine dyspepsia, ulcer-like, dysmotility-like and reflux-like prevalence after controlling the confounders.
Results: Among 590 respondents, the prevalence of dyspepsia was 54.6% (n = 322). Among them were 243 (41.2%) cases of uninvestigated dyspepsia. According to dyspepsia classification, the prevalence of ulcer-like, dysmotility-like, reflux-like and non-specific dyspepsia were 31.5% (n = 186), 11% (n = 65), 27.3% (n = 161) and 12.4% (n = 74), respectively. Difference in dyspepsia prevalence between men and women persisted after adjustment for other factors (p =0.01) and dyspepsia prevalence was higher in over-60-years old group than the middle aged group (p = 0.008). CONCLUSIONn: The study showed high prevalence of dyspepsia in the general population. Gender, age, family history and theophylline consumption affect the prevalence of dyspepsia.
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Neurogastroenterol Motil
January 2025
University of California Los Angeles David Geffen School of Medicine, California, Los Angeles, USA.
Background: Disorders of gut-brain interaction (DGBI) predominate in women, but little is known about sex differences in menses-related or menopause symptoms.
Methods: Using data from the Rome Foundation Global Epidemiology Survey, we assessed Rome IV DGBI symptoms in individuals in 26 countries who met criteria for ≥ 1 of 5 DGBI: irritable bowel syndrome (IBS), functional dyspepsia (FD), functional constipation (FC), functional diarrhea (FDr), or functional bloating (FB). Participants included pre- and post-menopausal women with DGBI and age-matched men.
Mymensingh Med J
January 2025
Dr Mohammad Reazul Karim, Associate Professor, Department of Gastroenterology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:
Helicobacter pylori (H pylori) infection is known to be associated with dyspepsia for more than three decades. This study was conducted to investigate the frequency of H pylori infection in functional dyspepsia. Helicobacter pylori infection was detected by stool antigen tests were analyzed in 102 patients with functional dyspepsia.
View Article and Find Full Text PDFSci Rep
December 2024
Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
No previous study has examined the association between coffee and caffeine intake and odds of functional dyspepsia (FD). The aim of this study was to investigate the association between coffee and caffeine intake and odds of FD and its components in a large sample of Iranian adults. In this cross-sectional study on 3362 adults aged 18-55 years, a validated food frequency questionnaire (DS-FFQ) was used to assess dietary intakes.
View Article and Find Full Text PDFEur Neuropsychopharmacol
December 2024
SCIENCES Lab, Department of Psychiatry, University of Ottawa, Ottawa, Canada; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany; Department of Mental Health, The Ottawa Hospital, Ottawa, Canada; Ottawa Hospital Research Institute: Clinical Epidemiology Program, University of Ottawa, Ottawa, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, Canada. Electronic address:
The United States Food and Drug Administration approved xanomeline-trospium combination for schizophrenia on September-26-2024. We conducted a PRISMA 2020-compliant systematic review with random-effects meta-analysis on the efficacy and safety of xanomeline-trospium in randomized controlled trials in patients with schizophrenia (MEDLINE, EMBASE, Cochrane, PsycINFO, October-01-2024). Co-primary outcomes were Positive And Negative Syndrome Scale (PANSS) total score (standardized mean difference=SMD), and all-cause discontinuation (risk ratio=RR).
View Article and Find Full Text PDFPediatr Int
December 2024
Department of Pediatric Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey.
Background: The Rome IV criteria offer symptom-based recommendations for diagnosing functional gastrointestinal diseases (FGID) in children and adolescents without esophagogastroduodenoscopy (EGD). The aim of this study is to evaluate the usefulness of Rome IV criteria for ruling out organic disease in patients with and without alarm symptoms.
Methods: Retrospective research was conducted on children and adolescents who had dyspepsia and underwent EGD.
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