Instrumental variables estimators are designed to provide consistent parameter estimates for linear regression models when some covariates are correlated with the error term. We propose a new robust instrumental variables estimator (RIV) which is a natural robustification of the ordinary instrumental variables estimator (OIV). Specifically, we construct RIV using a robust multivariate location and scatter S-estimator to robustify the solution of the estimating equations that define OIV. RIV is computationally inexpensive and readily available for applications through the R-library riv. It has attractive robustness and asymptotic properties, including high resilience to outliers, bounded influence function, consistency under weak distributional assumptions, asymptotic normality under mild regularity conditions, and equivariance. We further endow RIV with an iterative algorithm which allows for the estimation of models with endogenous continuous covariates and exogenous dummy covariates. We study the performance of RIV when the data contains outliers using an extensive Monte Carlo simulation study and by applying it to a limited-access dataset from the Framingham Heart Study-Cohort to estimate the effect of long-term systolic blood pressure on left atrial size.
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Background: As the prevalence of osteoporotic fractures increases, impacting the health of the aging population significantly, understanding the genetic link between chronic diseases such as primary biliary cholangitis (PBC) and osteoporosis (OP) is crucial. Despite existing research, the direct genetic relationship between these conditions remains unclear.
Materials And Methods: This study used a two-sample Mendelian randomization approach, drawing on the largest available genome-wide association studies.
Chem Biodivers
January 2025
University of Belgrade Faculty of Biology: Univerzitet u Beogradu Bioloski Fakultet, Plant morphology and systematics, Takovska 43, Belgrade, 11000, Belgrade, SERBIA.
The essential oil composition of 14 natural populations of two Juniperus oxycedrus s.l. taxa (J.
View Article and Find Full Text PDFBrain Behav Immun Health
February 2025
Department of Neurosurgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, Henan, 450003, China.
Background: Trigeminal neuralgia (TN) is a severe facial pain disorder with complex etiology. Inflammation has been suggested as a contributing factor to TN pathogenesis. This study investigates the causal relationship between inflammatory biomarkers, including 41 circulating inflammatory cytokines, C-reactive protein (CRP), and procalcitonin (PCT), and TN using Mendelian randomization (MR) analysis.
View Article and Find Full Text PDFEur J Heart Fail
January 2025
Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Inserm U1116, CHRU de Nancy and F-CRIN INI-CRCT, Nancy, France.
Aims: Early identification of healthy subjects prone to develop cardiac dysfunction may be instrumental to prevention strategies. Our study aimed to evaluate whether circulating levels of growth differentiation factor-15 (GDF-15) could predict adverse changes in echocardiographic indexes of cardiac structure and function in an initially healthy populational familial cohort with a long follow-up (STANISLAS cohort).
Methods And Results: We evaluated 1679 participants (49 ± 14 years, 48% males) included in the fourth visit (V4) of the STANISLAS cohort with available GDF-15 measurements (Olink proteomic analysis) and echocardiographic parameters.
Arch Dermatol Res
January 2025
Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 33 Badachu Road, Shijingshan, Beijing, 100144, China.
Breast cancer (BC) is a prevalent malignancy in women, often necessitating tumor resection and breast reconstruction surgeries. However, the post-operation scars can be of concern, as hypertrophic scars (HS) can profoundly impact patients' quality of life. Our study used the bidirectional Mendelian randomization (MR) method to explore the potential relationship between BC and HS.
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