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Epidemiologic Trends and Socioeconomic Disparities of Ankylosing Spondylitis in South Korea: A Nationwide Population-Based Study, 2010-2021.
Yonsei Med J
December 2024
Department of Precision Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Purpose: To investigate the epidemiological trends and socioeconomic disparities associated with ankylosing spondylitis (AS) in South Korea over a decade (2010-2021) using National Health Insurance Service (NHIS) claims data.
Materials And Methods: Employing data from the NHIS database, this study identified 31753 incident AS patients in 2010-2021. We calculated the annual age-standardized prevalence and incidence rates and analyzed crude incidence rates and diagnostic patterns across age groups.
HIPK3 hypomethylation as a potential epigenetic biomarker in rheumatic immune diseases with emphasis on rheumatoid arthritis.
Clin Rheumatol
November 2024
Department of Rheumatology, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Article Synopsis
- The study investigates HIPK3 DNA methylation as a potential biomarker for rheumatoid arthritis (RA) and its relationship with clinical indicators in multiple rheumatic diseases.
- Researchers analyzed methylation levels in 368 participants, using advanced sequencing technology, and discovered that HIPK3 methylation was significantly lower in RA, systemic lupus erythematosus (SLE), and dermatomyositis (DM) compared to healthy controls.
- Findings indicate a negative correlation between HIPK3 methylation levels and various clinical markers in RA, suggesting HIPK3 hypomethylation could serve as a diagnostic indicator for RA and related diseases.
ALKBH5 controlled autophagy of peripheral blood mononuclear cells by regulating NRG1 mRNA stability in ankylosing spondylitis.
Int Immunopharmacol
January 2025
Anhui Province Key Laboratory of Pollution Damage and Biological Control for Huaihe River Basin, Fuyang Normal University, 100 Qinghe West Road, Fuyang, Anhui 236041, PR China; Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Fuyang Normal University, 100 Qinghe West Road, Fuyang, Anhui 236041, PR China. Electronic address:
Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease which is characterized by pathological osteogenesis. N6-methyladenosine (m6A) RNA modification is pivotal in immunity and inflammation. In this study, the peripheral blood mononuclear cells (PBMCs) were isolated from healthy or AS patients blood samples in Fuyang People's Hospital, which was utilized to clarify the role of m6A modification in AS pathogenesis.
View Article and Find Full Text PDFHome Transcutaneous Electrical Stimulation Rehabilitation Program for Patients With Ankylosing Spondylitis: Crossover Trial.
JMIR Form Res
October 2024
Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Article Synopsis
- The study focuses on evaluating the effectiveness of a home-based TENS (transcutaneous electrical nerve stimulation) system designed for patients with ankylosing spondylitis (AS), a condition that affects spinal flexibility and function.
- Participants were split into two treatment groups (1-month and 2-month durations) to assess various health indicators like the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and functional scores.
- Results indicated improvements in functional scores after treatment, though scores worsened during a washout period, suggesting the TENS treatment may be beneficial for managing AS symptoms.
Gut microbiota dysbiosis in ankylosing spondylitis: a systematic review and meta-analysis.
Front Cell Infect Microbiol
October 2024
Department of Rheumatology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Background: Ankylosing spondylitis (AS) is a connective tissue disease that primarily affects spinal joints, peripheral joints, and paravertebral soft tissues, leading to joint stiffness and spinal deformity. Growing evidence has implicated gut microbiota in the regulation of AS, though the underlying mechanisms remain poorly understood.
Methods: We conducted a comprehensive search of PubMed, Embase, Web of Science, the Cochrane Library, MEDLINE, Wanfang Data, China Science and Technology Journal Database (VIP), and China National Knowledge Internet (CNKI) databases from the time the databases were created until 30 July 2023.
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