Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807283 | PMC |
| http://dx.doi.org/10.1128/JVI.01498-13 | DOI Listing |
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