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Role of the medial septum neurotensin receptor 1 in anxiety-like behaviors evoked by emotional stress.
Psychoneuroendocrinology
January 2025
Women and Children's Medical Research Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:
Anxiety is one of the most common mental disorders. Neurotensin (NT) is a neuropeptide widely distributed in the central nervous system, involved in the pathophysiology of many neural and psychiatric disorders such as anxiety. However, the neural substrates mediating NT's effect on the regulation of anxiety have not been fully identified.
View Article and Find Full Text PDFLocalisation of the relaxin-family peptide 3 receptor to enteroendocrine cells of the intestine in RXFP3-Cre/tdTomato mice.
Biochem Pharmacol
December 2024
Faculty of Health, School of Medicine, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Waurn Ponds, Victoria 3216, Australia.
The relaxin-family peptide 3 receptor (RXFP3) and its native ligand, relaxin-3, are expressed in specific populations of brain neurons, and research on this system has focused on its role in the central nervous system. However, some studies have indicated that relaxin-3 and RXFP3 are also expressed in peripheral organs, including the gut. In this study, we characterised the identity of RXFP3-expressing cells in the gastrointestinal tract, using RXFP3-Cre/tdTomato reporter mice.
View Article and Find Full Text PDFNeurotensin-expressing lateral hypothalamic neurons alleviate neuropathic and inflammatory pain via neurotensin receptor signaling.
Neurobiol Pain
October 2024
Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.
Persistent, severe pain negatively impacts health and wellbeing, but half of patients do not receive adequate relief from current treatments. Understanding signals that modulate central pain processing could point to new strategies to manage severe pain. Administering Neurotensin (Nts) or Nts receptor (NtsR) agonists into the brain provides analgesia comparable to pharmacologic opioids.
View Article and Find Full Text PDFGeneral anesthesia activates a central anxiolytic center in the BNST.
Cell Rep
November 2024
McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Article Synopsis
- - Low doses of anesthetics like ketamine and dexmedetomidine show anxiety-reducing effects that are independent of their sedative qualities, but how they work is still not fully understood.
- - Researchers found a specific group of GABAergic neurons, called ovBNST, that respond to anesthetics and anxiolytic drugs, forming connections with brain areas involved in managing anxiety and stress.
- - Activating these ovBNST neurons can significantly reduce anxiety behaviors, while shutting them down increases anxiety, indicating their role in managing autonomic responses and suggesting they could be a target for treating anxiety disorders.
Metabolic dysfunction-associated steatotic liver disease: A pathophysiology and clinical framework to face the present and the future.
Nutr Metab Cardiovasc Dis
August 2024
Department of Clinical Medicine, Internal Medicine Unit, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy.
Aims: This review aims to provide a straightforward conceptual framework for the knowledge and understanding of Metabolic dysfunction-associated steatotic liver disease (MASLD) in the broad spectrum of steatotic liver disease and to point out the need to consider metabolic dysfunction and comorbidities as interrelated factors for a holistic approach to fatty liver disease.
Data Synthesis: MASLD is the new proposed term for steatotic liver disease that replaces the old terminology of non-alcoholic fatty liver disease. This term focused on the relationship between metabolic alteration and hepatic steatosis, reflecting a growing comprehension of the association between metabolic dysfunction and hepatic steatosis.
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